cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester

Base Information

• Chemical Name: cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester
• CAS No.: 38410-81-0
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.197
• Mol file: 38410-81-0.mol

Synonyms:

Chemical Property of cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester

There total 2 articles about cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

trans-2,3-Epoxy-buttersaeuremethylester (10133-07-0) + acetone (67-64-1) → cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester (36183-27-4,38410-80-9,38410-81-0,63640-49-3,78086-72-3,81939-14-2,84894-21-3,117181-61-0,151005-02-6)

Guidance literature:

With tin(IV) chloride; In tetrachloromethane; at -35 ℃;

Reference yield: 71.0%

methyl (+/-)-trans-(2,3)-epoxy butanoate (10133-06-9,10133-07-0,10133-45-6,50468-20-7,59123-20-5,83057-88-9,121252-25-3,129311-57-5,136889-92-4,2980-48-5) + acetone (67-64-1) → cis-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure-methylester (36183-27-4,38410-80-9,38410-81-0,63640-49-3,78086-72-3,81939-14-2,84894-21-3,117181-61-0,151005-02-6)

Guidance literature:

With tin(IV) chloride; In tetrachloromethane; 1.) -30 deg C, 30 min, 2.) r.t., 1 h;

Reference yield: 62.0%

methyl 4(R),5(R)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylate (38410-81-0) → 4(R),5(R)-2,2,5-trimethyl-1,3-dioxolane-4-carboxaldehyde (112709-74-7)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; at -50 ℃;

upstream raw materials:

methyl (+/-)-trans-(2,3)-epoxy butanoate

acetone

trans-2,3-Epoxy-buttersaeuremethylester

Downstream raw materials:

4(R),5(R)-2,2,5-trimethyl-1,3-dioxolane-4-carboxaldehyde

(+/-)-2,2,5-trimethyl-cis-1,3-dioxolane-4-carboxaldehyde

Refernces

• 1、 Ladner, Wolfgang. ""Kontra-sterische" Alkylierung der Enolate von Dioxolancarbonsaeureestern". . p. 459 - 460. Retrieved 2007/10/02.