2,3-DiMethyl-cyclopropanecarboxylic acid, (Methyl cis)

Base Information

• Chemical Name: 2,3-DiMethyl-cyclopropanecarboxylic acid, (Methyl cis)
• CAS No.: 34669-52-8
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.144
• Mol file: 34669-52-8.mol

Synonyms:

Chemical Property of 2,3-DiMethyl-cyclopropanecarboxylic acid, (Methyl cis)

Chemical Property:

Purity/Quality:

(2R,3S)-1,2,3-Trimethylcyclopropane-1-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-DiMethyl-cyclopropanecarboxylic acid, (Methyl cis)

There total 6 articles about 2,3-DiMethyl-cyclopropanecarboxylic acid, (Methyl cis) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-2,3-dimethylcyclopropane carboxylic acid (17219-23-7,20431-63-4,20431-71-4,20431-72-5,34669-50-6,34669-51-7,34669-52-8) → (-)-trans-2,3-Dimethyl-cyclopropancarbonsaeure (17219-23-7,20431-63-4,20431-71-4,20431-72-5,34669-50-6,34669-51-7,34669-52-8)

Guidance literature:

Multistep reaction; (i) quinine, EtOH, (ii) aq. KOH, MeOH;

DOI:10.1021/ja01013a029

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + trans-2-Butene (624-64-6) → trans-2,3-dimethylcyclopropane carboxylic acid (17219-23-7,20431-63-4,20431-71-4,20431-72-5,34669-50-6,34669-51-7,34669-52-8)

Guidance literature:

Multistep reaction; (i) CuCl, (ii) (saponification);

DOI:10.1016/S0040-4020(01)91691-6

Reference yield:

trans-2,3-dimethylcyclopropane carboxylic acid (17219-23-7,20431-63-4,20431-71-4,20431-72-5,34669-50-6,34669-51-7,34669-52-8) → (+)-trans-2,3-Dimethyl-cyclopropancarbonsaeure (17219-23-7,20431-63-4,20431-71-4,20431-72-5,34669-50-6,34669-51-7,34669-52-8)

Guidance literature:

Multistep reaction; (i) quinine, EtOH, (ii) aq. KOH, MeOH;

DOI:10.1021/ja01013a029

upstream raw materials:

(Z)-2-Butene

methyl diazoacetate

diazoacetic acid ethyl ester

trans-2-Butene

Downstream raw materials:

(+)-trans-2,3-Dimethyl-cyclopropancarbonsaeure

(-)-trans-2,3-Dimethyl-cyclopropancarbonsaeure

1-((2R,3R)-2,3-Dimethyl-cyclopropyl)-ethanone

benzyl (3aS,6S,6aR)-4-{[cis-2,3-dimethylcyclopropyl]-cis-carbonyl}-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate