1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane

Base Information

• Chemical Name: 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane
• CAS No.: 1176327-53-9
• Molecular Formula: C₄₈H₅₀As₂Cl₂N₂
• Molecular Weight: 875.688
• Mol file: 1176327-53-9.mol

Synonyms:

Chemical Property of 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane

There total 7 articles about 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

[2,6-bis-(2,4,6-trimethylphenyl)phenyl]amino(dichloro)arsane (1176327-66-4) → 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane (1176327-53-9,1257432-62-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at -80 - 20 ℃; for 4.25h; Inert atmosphere;

DOI:10.1039/c0dt00700e

Reference yield:

2-mesitylmagnesium bromide (2633-66-1) → 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane (1176327-53-9,1257432-62-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -80 °C / Inert atmosphere

1.2: 14 h / -80 °C / Inert atmosphere; Reflux

2.1: iodine / tetrahydrofuran / 11 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether / 1.5 h / 0 °C / Inert atmosphere

3.2: 2.25 h / 0 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether / 3.33 h / -60 °C / Inert atmosphere; Reflux

5.1: n-butyllithium / diethyl ether / 1 h / 20 °C / Inert atmosphere

5.2: 3 h / 20 °C / Inert atmosphere

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4.25 h / -80 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether;

DOI:10.1039/c0dt00700e

Reference yield:

2,4,6,2'',4'',6''-hexamethyl-1,1':3',1''-terphenyl (103068-13-9) → 1,3-dichloro-2,4-bis[2,4-bis-(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazane (1176327-53-9,1257432-62-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: iodine / tetrahydrofuran / 11 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether / 1.5 h / 0 °C / Inert atmosphere

2.2: 2.25 h / 0 - 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 3.33 h / -60 °C / Inert atmosphere; Reflux

4.1: n-butyllithium / diethyl ether / 1 h / 20 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4.25 h / -80 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether;

DOI:10.1039/c0dt00700e

upstream raw materials:

2,6-bis-(2,4,6-trimethylphenyl)aniline

2'-azido-2,4,6,2'',4'',6''-hexamethyl-[1,1';3',1'']terphenyl

[2,6-bis-(2,4,6-trimethylphenyl)phenyl]amino(dichloro)arsane

2,4,6,2'',4'',6''-hexamethyl-1,1':3',1''-terphenyl

Downstream raw materials:

1-chloro-2,4-bis[2,4-bis(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazenium μ-azido-bis[hexachloridogallium(III)]

1-azido-2,4-bis[2,4-bis(2,4,6-trimethylphenyl)phenyl]-cyclo-1,3-diarsa-2,4-diazenium μ-azido-bis[hexachloridogallium(III)]