C₃₂H₅₃NO₃Si₂

Base Information

• Chemical Name: C₃₂H₅₃NO₃Si₂
• CAS No.: 1404213-30-4
• Molecular Formula: C₃₂H₅₃NO₃Si₂
• Molecular Weight: 555.949
• Mol file: 1404213-30-4.mol

Synonyms:

Chemical Property of C₃₂H₅₃NO₃Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₅₃NO₃Si₂

There total 6 articles about C₃₂H₅₃NO₃Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H35I2NO3 (1404213-29-1) + trimethylsilylacetylene (1066-54-2) → C32H53NO3Si2 (1404213-30-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201200655

Reference yield:

tert-butyl (4-hydroxybenzyl)carbamate (149505-94-2) → C32H53NO3Si2 (1404213-30-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium chlorite; sodium iodide / methanol; water

1.2: 20 °C

2.1: potassium carbonate / acetone / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 2 h

3.2: 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

5.1: sodium iodide; potassium carbonate / acetone / Reflux

6.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; copper(l) iodide; boron tribromide; potassium carbonate; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; 6.1: |Sonogashira Cross-Coupling;

DOI:10.1002/ejoc.201200655

Reference yield:

tert-butyl 3,5-diiodophenyl-4-methoxy methylcarbamate (1372787-73-9) → C32H53NO3Si2 (1404213-30-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h

1.2: 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: sodium iodide; potassium carbonate / acetone / Reflux

4.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron tribromide; potassium carbonate; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; dichloromethane; acetone; 4.1: |Sonogashira Cross-Coupling;

DOI:10.1002/ejoc.201200655

upstream raw materials:

C₂₂H₃₅I₂NO₃

trimethylsilylacetylene

tert-butyl (4-hydroxybenzyl)carbamate

tert-butyl 4-hydroxy-3,5-diiodobenzylcarbamate

Downstream raw materials:

C₄₆H₅₃NO₃

C₆₈H₇₇I₂N₃O₇