C₂₆H₃₆N₆O₄

Base Information

• Chemical Name: C₂₆H₃₆N₆O₄
• CAS No.: 1207358-49-3
• Molecular Formula: C₂₆H₃₆N₆O₄
• Molecular Weight: 496.61
• Mol file: 1207358-49-3.mol

Synonyms:

Chemical Property of C₂₆H₃₆N₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₆N₆O₄

There total 7 articles about C₂₆H₃₆N₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-ethylureido)phenylboronic acid, pinacol ester (882038-99-5) + C17H25ClN4O3 (1245251-91-5) → C26H36N6O4 (1207358-49-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; In water; acetonitrile; at 120 ℃; Microwave irradiation;

DOI:10.1021/jm301389h

Reference yield:

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1208901-69-2,635698-30-5) → C26H36N6O4 (1207358-49-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetraalkylammonium carbonate polymer-bound resin / dichloromethane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3: |Suzuki Coupling;

DOI:10.1021/jm301389h

Reference yield:

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester (57611-47-9) → C26H36N6O4 (1207358-49-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 96 h / Reflux; Inert atmosphere

2.1: trichlorophosphate / 3 h / Inert atmosphere

3.1: 2-Chloroethyl chloroformate / dichloromethane / 1.25 h / 0 - 20 °C

3.2: 0.5 h / Reflux

4.1: tetraalkylammonium carbonate polymer-bound resin / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium acetate; sodium carbonate; 2-Chloroethyl chloroformate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: |Suzuki Coupling;

DOI:10.1021/jm301389h

upstream raw materials:

(4-ethylureido)phenylboronic acid, pinacol ester

C₁₇H₂₅ClN₄O₃

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

Downstream raw materials:

C₂₁H₂₈N₆O₂