N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

Base Information

• Chemical Name: N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide
• CAS No.: 869286-16-8
• Molecular Formula: C₄₆H₇₆N₁₀O₉
• Molecular Weight: 913.171
• Mol file: 869286-16-8.mol

Synonyms:

Chemical Property of N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide

There total 1 articles about N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl]phenylamine (497969-01-4) → N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide (869286-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62.26 percent / Na₂CO₃ / dioxane / 20 °C

2: 77 percent / Cs₂CO₃ / acetonitrile / 72 h / 72 °C

With sodium carbonate; caesium carbonate; In 1,4-dioxane; acetonitrile;

DOI:10.1039/b509230m

Reference yield: 36.0%

terbium(III) trifluoromethanesulfonate + N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide (869286-16-8) → ((C2H4N(CH2CON(CH3)2))3C2H4N(CH2CONHC6H3(OCH3)N(C2H4O)2C2H4N(C7H7O)C2H4OC2H4))Tb(H2O)(3+)*3O3SCF3(1-)=C49H78N10O19F9S3Tb

Guidance literature:

In acetonitrile; ligand and Tb compd. (1.1 equiv.) were added to MeCN; soln. was freeze-pump-thawed; stirred under reflux for 24 h under Ar; cooled to room temp.; dropped slowly onto Et2O; decanted; dissolved in CH2Cl2; chromd. (alumina, CH2Cl2/THF, 70/30, CH2Cl2/THF/MeOH, 60/30/10);

DOI:10.1039/b509230m

Reference yield:

terbium(III) trifluoromethanesulfonate + N-{3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadec-7-yl]phenyl}-2-(4,7,10-tris(dimethylcarbamoyl)-methyl-1,4,7,10-tetraazacyclododec-1-yl)acetamide (869286-16-8) → Tb(3+)*CH3OC6H4(N2O3C10H20)C6H3(OCH3)NHCOCH2(N4C8H16)(CH2C(O)N(CH3)2)3*3(CF3SO3)(1-)=[Tb(C46H76N10O9)](CF3SO3)3

Guidance literature:

In acetonitrile; refluxing equimolar amounts in dry CH3CN; pptn. by addition to diethyl ether, purified on alumina;

DOI:10.1039/b307055g

upstream raw materials:

3-methoxy-4-[13-(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl]phenylamine