octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Base Information

• Chemical Name: octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester
• CAS No.: 820216-54-4
• Molecular Formula: C₃₇H₅₅N₃O₆S₃Si
• Molecular Weight: 762.144
• Mol file: 820216-54-4.mol

Synonyms:

Chemical Property of octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

There total 11 articles about octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-(2-aminopropyl)-7-benzyloxyindole (244081-35-4) → octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester (820216-54-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / CHCl₃

2: 99 percent / HCO₂NH₄ / Pd/C / methanol

3: TEA / CH₂Cl₂

4: HCl / ethyl acetate

5: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

(2R)-7-benzyloxy-3-[2-(tert-butoxycarbonylamino)propyl]-1H-indole (244081-38-7) → octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester (820216-54-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / HCO₂NH₄ / Pd/C / methanol

2: TEA / CH₂Cl₂

3: HCl / ethyl acetate

4: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

octane-1-sulfonyl chloride (7795-95-1) → octane-1-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester (820216-54-4)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂

2: HCl / ethyl acetate

3: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; potassium iodide; In dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2004.10.035

upstream raw materials:

(R)-N-{3-[2-bromo-1-(tert-butyldimethylsilyloxy)ethyl]phenyl}(2-thiophene)sulfonamide

octane-1-sulfonic acid 3-(2-amino-propyl)-1H-indol-7-yl ester

octane-1-sulfonyl chloride

tert-butyldimethylsilyl chloride