Cyclopenta[b]pyrrole-2-carboxylic acid, 1,4,5,6-tetrahydro-4-oxo

Base Information

• Chemical Name: Cyclopenta[b]pyrrole-2-carboxylic acid, 1,4,5,6-tetrahydro-4-oxo
• CAS No.: 1041429-47-3
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.148
• Mol file: 1041429-47-3.mol

Synonyms:

Chemical Property of Cyclopenta[b]pyrrole-2-carboxylic acid, 1,4,5,6-tetrahydro-4-oxo

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4-OXO-1,4,5,6-TETRAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopenta[b]pyrrole-2-carboxylic acid, 1,4,5,6-tetrahydro-4-oxo

There total 4 articles about Cyclopenta[b]pyrrole-2-carboxylic acid, 1,4,5,6-tetrahydro-4-oxo which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C10H11NO3 (1142816-48-5) → 4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (1041429-47-3)

Guidance literature:

C₁₀H₁₁NO₃; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 4h;

With hydrogenchloride; In methanol; water; pH=2;

Reference yield:

1-(N-morpholino)cyclopent-1-ene (936-52-7) → 4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (1041429-47-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 3.5 h / 20 °C

1.2: 3 h / 130 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; tetrahydrofuran / 4 h / 0 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 70 °C

3.2: pH 2

With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

ethyl 1,4,5,6-tetrahydrocyclopentadieno[b]pyrrole-2-carboxylate (124455-77-2) → 4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (1041429-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; tetrahydrofuran / 4 h / 0 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 70 °C

2.2: pH 2

With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; water;

upstream raw materials:

1-(N-morpholino)cyclopent-1-ene

ethyl 1,4,5,6-tetrahydrocyclopentadieno[b]pyrrole-2-carboxylate

C₁₀H₁₁NO₃