1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester
• CAS No.: 124455-77-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 124455-77-2.mol

Synonyms:ethyl 1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate;1,4,5,6-TETRAHYDRO-CYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER;

Chemical Property of 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester

Chemical Property:

• PSA: 42.09000
• LogP: 1.68010

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester

There total 7 articles about 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 3-(2-azidocyclopent-2-enylidene)-propionate (124455-68-1) → ethyl 1,4,5,6-tetrahydrocyclopentadieno[b]pyrrole-2-carboxylate (124455-77-2)

Guidance literature:

In xylene; for 16h; Heating;

Reference yield: 34.0%

1-(N-morpholino)cyclopent-1-ene (936-52-7) + ethyl 3-bromo-2-(hydroxyimino)propanoate (73472-94-3) → ethyl 1,4,5,6-tetrahydrocyclopentadieno[b]pyrrole-2-carboxylate (124455-77-2)

Guidance literature:

1-(N-morpholino)cyclopent-1-ene; ethyl 3-bromo-2-(hydroxyimino)propanoate; In toluene; at 20 ℃; for 3.5h;

With triiron dodecarbonyl; trifluoroacetic acid; In toluene; at 130 ℃; for 3h;

Reference yield: 31.0%

(E)-3-(2-chlorocyclopenta-1-ene-1-yl) ethyl acrylate → ethyl 1,4,5,6-tetrahydrocyclopentadieno[b]pyrrole-2-carboxylate (124455-77-2)

Guidance literature:

With sodium azide; at 65 ℃; for 12h;

upstream raw materials:

ethyl 3-(2-azidocyclopent-2-enylidene)-propionate

2-chlorocyclopent-1-ene-1-carbaldehyde

2-Azido-1-cyclopentene-1-carboxaldehyde

ethyl 3-(2-azidocyclopent-1-enyl)-3-hydroxypropionate

Downstream raw materials:

1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

3-phenyl-2(RS)-{2-[(1,4,5,6-tetrahydro-cyclopenta[b]pyrrole-2-carbonyl)-amino]-benzoylamino}-propionic acid ethyl ester

ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid