(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid

Base Information

Chemical Name:(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid
CAS No.:124321-65-9
Molecular Formula:C₃₆H₅₃N₅O₇
Molecular Weight:667.846
Hs Code.:

(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid

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Chemical Property of (R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid

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Technology Process of (R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid

There total 12 articles about (R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 124322-11-8,124378-13-8
(phenylacetyl)-α-benzyl-β-L-aspartyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

: 124321-65-9,124378-05-8
(phenylacetyl)-β-L-aspartyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: With ammonium formate; palladium on activated charcoal; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jm00167a009

Reference yield:

: 124322-11-8,124378-13-8
(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester

: 124321-65-9,124378-05-8
(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid

Guidance literature:: With ammonium formate; palladium on activated charcoal; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jm00167a009

Reference yield:

: 103-82-2
phenylacetic acid

: 124321-65-9,124378-05-8
(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂

2: ammonium formate / 10percent Pd/C / dimethylformamide / 3 h / Ambient temperature

With diethylphosphoryl cyanide; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a009