(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester

Base Information

Chemical Name:(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester
CAS No.:124322-11-8
Molecular Formula:C₄₃H₅₉N₅O₇
Molecular Weight:757.971
Hs Code.:

(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester

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Chemical Property of (R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester

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Technology Process of (R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester

There total 10 articles about (R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 103-82-2
phenylacetic acid

: 124322-10-7,124378-12-7
(S)-2-Amino-N-((1S,2S,4S)-2-hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-succinamic acid benzyl ester

: 124322-11-8,124378-13-8
(phenylacetyl)-α-benzyl-β-L-aspartyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: With diethylphosphoryl cyanide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm00167a009

Reference yield:

: 92828-64-3
(R)-2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 124322-11-8,124378-13-8
(R)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetylamino-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

2: trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / Ambient temperature

3: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂

With diethylphosphoryl cyanide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00167a009

Reference yield:

: 30925-18-9
2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 124322-11-8,124378-13-8
(phenylacetyl)-α-benzyl-β-L-aspartyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

2: 641.3 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / Ambient temperature

3: 64 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂

With diethylphosphoryl cyanide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00167a009