(25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine

Base Information

• Chemical Name: (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine
• CAS No.: 1372893-01-0
• Molecular Formula: C₂₅H₂₆FN₅O₂
• Molecular Weight: 447.512
• Mol file: 1372893-01-0.mol

Synonyms:

Chemical Property of (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine

There total 5 articles about (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(2-(3-((dimethylamino)methyl)-2-methoxyphenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanone (1372892-97-1) + 4-fluoroaniline (371-40-4) → (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine (1372893-01-0)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.2298/JSC110123155M

Reference yield:

isoniazid (54-85-3,7640-37-1) → (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine (1372893-01-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 7 h / Reflux

2: hydrogenchloride / ethanol; water / 35 h / pH 4 / Reflux

3: 7 h / Reflux

4: acetic acid / ethanol / Reflux

With hydrogenchloride; acetic acid; In ethanol; water;

DOI:10.2298/JSC110123155M

Reference yield:

(E)-N'-{3-[(dimethylamino)methyl]-2-methoxybenzylidene}isonicotinoyl hydrazide (1372892-96-0) → (25Z)-N-(1-[2-{3-[(dimethylamino)methyl]-2-methoxyphenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethylidene)-4-fluorobenzenamine (1372893-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 7 h / Reflux

2: acetic acid / ethanol / Reflux

With acetic acid; In ethanol;

DOI:10.2298/JSC110123155M

upstream raw materials:

isoniazid

(E)-N'-{3-[(dimethylamino)methyl]-2-methoxybenzylidene}isonicotinoyl hydrazide

1-(2-(3-((dimethylamino)methyl)-2-methoxyphenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanone

4-fluoroaniline

Refernces

• 1、 Malhotra, Manav,Hans, Pankhuri,Sharma, Sagun,Deep, Aakash,Phogat, Priyanka. "Synthesis and characterization of (Z)-N-(1-[2-{3-[(dimethylamino)methyl)]- 2-methoxyphenyl}-5-(pyridin-4-YL)-1,3,4-oxadiazol-3(2H)-YL]ethylidene) benzenamine derivatives as potent antifungal agents". . p. 433 - 438. Retrieved 2012/09/07.