7-(4-Chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide

Base Information

Chemical Name:7-(4-Chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide
CAS No.:120450-23-9
Molecular Formula:C₁₆H₁₄ClN₃O
Molecular Weight:299.76
Hs Code.:
DSSTox Substance ID:DTXSID501156554

Synonyms:7-(4-chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide;120450-23-9;Oprea1_497368;DTXSID501156554;MFCD00231446;AKOS015991660;10F-919

Suppliers and Price of 7-(4-Chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(4-Chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:299.0825398
Heavy Atom Count:21
Complexity:397

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=NC2=C(C(=CN12)C3=CC=C(C=C3)Cl)C(=O)N)C

Technology Process of 7-(4-Chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide

There total 3 articles about 7-(4-Chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 120450-13-7
7-(4-Chloro-phenyl)-2,4-dimethyl-pyrrolo[1,2-a]pyrimidine-8-carbonitrile

: 120450-23-9
7-(4-Chloro-phenyl)-2,4-dimethyl-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid amide

Guidance literature:: With phosphoric acid; at 110 - 120 ℃; for 2h;

Reference yield:

: 120450-07-9
2-amino-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile

: 120450-23-9
7-(4-Chloro-phenyl)-2,4-dimethyl-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / 4 h / Heating

2: 74 percent / 85percent H₃PO₄, PPA / 2 h / 110 - 120 °C

With phosphoric acid; In pyridine;

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 120450-23-9
7-(4-Chloro-phenyl)-2,4-dimethyl-pyrrolo[1,2-a]pyrimidine-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / 4 h / Heating

2: 74 percent / 85percent H₃PO₄, PPA / 2 h / 110 - 120 °C

With phosphoric acid; In pyridine;