Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

Base Information

• Chemical Name: Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester
• CAS No.: 201210-74-4
• Molecular Formula: C₁₅H₈F₆N₂O₆
• Molecular Weight: 426.229
• Mol file: 201210-74-4.mol

Synonyms:

Chemical Property of Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

There total 3 articles about Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyloxycarbonylpropionic acid chloromethyl ester (143869-67-4) → Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester (201210-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / Et₃N / dimethylformamide / 16 h / Ambient temperature

2: 99 percent / 1,4-cyclohexadiene / Pd/C / acetic acid / 1 h / Ambient temperature

3: 43 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

With cyclohexa-1,4-diene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jo971076p

Reference yield:

Succinic acid benzyl ester phenylsulfanylmethyl ester (201210-68-6) → Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester (201210-74-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) SO₂Cl₂, 2.) cis-4-cyclohexene-1,2-dicarboxylic acid / 1.) CH₂Cl₂, room temperature, 1 h, 2.) 1 h

2: 76 percent / Et₃N / dimethylformamide / 16 h / Ambient temperature

3: 99 percent / 1,4-cyclohexadiene / Pd/C / acetic acid / 1 h / Ambient temperature

4: 43 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

With sulfuryl dichloride; cyclohexa-1,4-diene; cis-1,2,3,6-tetrahydrophthalic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jo971076p

Reference yield:

succinic acid benzyl ester (5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl ester (201210-70-0) → Succinic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester (201210-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / 1,4-cyclohexadiene / Pd/C / acetic acid / 1 h / Ambient temperature

2: 43 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

With cyclohexa-1,4-diene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jo971076p

upstream raw materials:

3-benzyloxycarbonylpropionic acid chloromethyl ester

Succinic acid benzyl ester phenylsulfanylmethyl ester

succinic acid benzyl ester (5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl ester