Technology Process of Iodo(4-methylenecyclohexyl)acetonitrile
There total 7 articles about Iodo(4-methylenecyclohexyl)acetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / H2 / Raney nickel / ethanol / 48 h / 100 °C / 76000 Torr
2: 92 percent / Na2Cr2O7, H2SO4 / diethyl ether; H2O / 3 h
3: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C
4: 92 percent / LiAlH4 / diethyl ether / 2 h / Heating
5: 95 percent / pyridine / 24 h / Ambient temperature
6: 93 percent / dimethylsulfoxide / 2 h / 50 °C
7: 1) LDA / 1) hexane, THF, HMPA, > -70 deg C, 5 min, 2) THF, to r.t.
With
pyridine; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; hydrogen; sodium hydride; lithium diisopropyl amide;
nickel;
In
diethyl ether; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jo00060a029
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92 percent / Na2Cr2O7, H2SO4 / diethyl ether; H2O / 3 h
2: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C
3: 92 percent / LiAlH4 / diethyl ether / 2 h / Heating
4: 95 percent / pyridine / 24 h / Ambient temperature
5: 93 percent / dimethylsulfoxide / 2 h / 50 °C
6: 1) LDA / 1) hexane, THF, HMPA, > -70 deg C, 5 min, 2) THF, to r.t.
With
pyridine; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; sodium hydride; lithium diisopropyl amide;
In
diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/jo00060a029
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / pyridine / 24 h / Ambient temperature
2: 93 percent / dimethylsulfoxide / 2 h / 50 °C
3: 1) LDA / 1) hexane, THF, HMPA, > -70 deg C, 5 min, 2) THF, to r.t.
With
pyridine; lithium diisopropyl amide;
In
dimethyl sulfoxide;
DOI:10.1021/jo00060a029
