1004-24-6

Basic information

• Product Name: 4-METHYLENECYCLOHEXYLMETHANOL
• Synonyms: 1-Hydroxymethly-4-methylenecyclohexane;4-Methylenecyclohexanemethanol;4-METHYLENECYCLOHEXYLMETHANOL;Cyclohexanemethanol, 4-methylene;(4-methylidenecyclohexyl)methanol
• CAS NO: 1004-24-6
• Molecular Formula: C₈H₁₄O
• Molecular Weight: 126.2
• Mol File: 1004-24-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 192.8°Cat760mmHg
• Flash Point: 79.4°C
• Appearance: /
• Density: 0.93g/cm³
• Vapor Pressure: 0.127mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.96±0.10(Predicted)
• CAS DataBase Reference: 4-METHYLENECYCLOHEXYLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLENECYCLOHEXYLMETHANOL(1004-24-6)
• EPA Substance Registry System: 4-METHYLENECYCLOHEXYLMETHANOL(1004-24-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1004-24-6(Hazardous Substances Data)

Usage

General Description

4-METHYLENECYCLOHEXYLMETHANOL is a chemical compound used in various industries, including fragrance, flavor, and pharmaceuticals. It is a colorless liquid with a slightly sweet aroma, and it is often used as a fragrance ingredient in personal care products and cosmetics. The compound is also utilized in the synthesis of other chemicals such as pharmaceuticals and agrochemicals. Furthermore, it is known for its potential as a skin irritant, and safety precautions should be taken when handling and using this chemical.

InChI:InChI=1/C8H14O/c1-7-2-4-8(6-9)5-3-7/h8-9H,1-6H2

Upstream product

• 3236-47-3 (1s,4s)-cyclohexane-1,4-diyldimethanol 
• 3399-21-1 cis-dimethyl 1,4-cyclohexanedicarboxylate 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 145576-28-9 ethyl 4-methylidenecyclohexanecarboxylate 
• 934-69-0 4-methylenecyclohexanecarboxylic acid 
• 116076-50-7 (1,4-cis-cyclohexanediyl)bis(methylene)dimethanesultonate 
• 115506-09-7 trans-1,4-bis-methanesulfonyloxymethyl-cyclohexane 

Downstream Products

• 147151-56-2 Iodo(4-methylenecyclohexyl)acetonitrile 
• 71707-69-2 (4-Methylenecyclohexyl)acetonitrile 
• 76825-09-7 (4-Methylenecyclohexylmethyl)bromide 
• 2808-80-2 4-methyl-1-methylidenecyclohexane 
• 89402-20-0 4-methylenecyclohexanecarbaldehyde 
• 147151-51-7 1-<(Tosyloxy)methyl>-4-methylenecyclohexane 
• 73588-14-4 (E)-4-(4-Hydroxymethyl-cyclohex-1-enyl)-but-2-enoic acid methyl ester 
• 1228182-62-4 Methanesulfonic acid 4-methylene-cyclohexylmethyl ester 
• 33775-91-6 (4-Vinylidene-cyclohexyl)-methanol 
• 71707-72-7 3,5-dinitro-benzoic acid-(4-methylene-cyclohexylmethyl ester) 
• 849671-56-3 spiro[2.5]octan-6-ylmethanol 

Relevant articles and documents

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Synthesis of Bridgehead-Substituted Bicycloheptanes by Radical Cyclization

A kinetic investigation shows that the rate of cyclization (kC) of the (4-methylenecyclohexyl)methyl radical 3 at 25 deg C is 4.4 x 102 s-1, which is considerably slower than that (2.3 x 105 s-1) of the parent 5-hexenyl radical.The energy of activation for the process 3 -> 4 is 12.8 kcal mol-1, which is in excellent agreement with theoretical values derived from force-field calculations.Ring-closure of appropriately substituted (4-methylenecyclohexyl)methyl radical precursors allows the synthesis of bicycloheptyl systems with useful functionality at the bridgehead to be achieved readily and in high yield.An interesting example is given of the application of an iodine-atom-transfer cyclization to the synthesis of a bicycloheptane functionalized at C7 and C1.