Technology Process of 5-benzyloxy-4-(4-benzyloxy-phenyl)-6-methoxy-2-methyl-1,2-dihydro-isoquinoline
There total 7 articles about 5-benzyloxy-4-(4-benzyloxy-phenyl)-6-methoxy-2-methyl-1,2-dihydro-isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / Ph3P, DEAD / tetrahydrofuran / 0.67 h / 25 °C
2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C
3: NMO, 3 Angstroem molecular sieves, TPAP / acetonitrile / 0.5 h / 25 °C
4: 89 percent / 2-methylbut-2-ene, NaClO2, H2O, Na2HPO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 8 h / 25 °C
5: 82 percent / DCC, DMAP / CH2Cl2 / 2 h / Ambient temperature
6: 82 percent / KHMDS / tetrahydrofuran; toluene / 1.) -78 deg C, 30 min, 2.) r.t., 30 min
7: LiAlH4 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) reflux, 2 h
With
dmap; sodium chlorite; disodium hydrogenphosphate; lithium aluminium tetrahydride; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 3 A molecular sieve; water; potassium hexamethylsilazane; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1039/a809925a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / Ph3P, DEAD / tetrahydrofuran / 0.67 h / 25 °C
2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C
3: NMO, 3 Angstroem molecular sieves, TPAP / acetonitrile / 0.5 h / 25 °C
4: 89 percent / 2-methylbut-2-ene, NaClO2, H2O, Na2HPO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 8 h / 25 °C
5: 82 percent / DCC, DMAP / CH2Cl2 / 2 h / Ambient temperature
6: 82 percent / KHMDS / tetrahydrofuran; toluene / 1.) -78 deg C, 30 min, 2.) r.t., 30 min
7: LiAlH4 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) reflux, 2 h
With
dmap; sodium chlorite; disodium hydrogenphosphate; lithium aluminium tetrahydride; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 3 A molecular sieve; water; potassium hexamethylsilazane; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1039/a809925a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / 2-methylbut-2-ene, NaClO2, H2O, Na2HPO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 8 h / 25 °C
2: 82 percent / DCC, DMAP / CH2Cl2 / 2 h / Ambient temperature
3: 82 percent / KHMDS / tetrahydrofuran; toluene / 1.) -78 deg C, 30 min, 2.) r.t., 30 min
4: LiAlH4 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) reflux, 2 h
With
dmap; sodium chlorite; disodium hydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; water; potassium hexamethylsilazane; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1039/a809925a
