(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester
CAS No.:252272-71-2
Molecular Formula:C₄₆H₄₆N₂O₆
Molecular Weight:722.881
Hs Code.:

(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

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Chemical Property of (S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

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Technology Process of (S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

There total 6 articles about (S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252272-41-6
(R)-2-methoxy-3-(2-naphthylmethoxy)-1-propanol

: 252272-71-2
(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / NBS, PPh₃ / CH₂Cl₂ / Ambient temperature

2: 72 percent / NaH / dimethylformamide / 80 °C

3: 87 percent / 60percent AcOH / Heating

4: CH₂Cl₂ / Ambient temperature

With N-Bromosuccinimide; sodium hydride; acetic acid; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/CC9960001073

Reference yield:

: 252272-47-2
(S)-1-bromo-2-methoxy-3-(2-naphthylmethoxy)propane

: 252272-71-2
(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / NaH / dimethylformamide / 80 °C

2: 87 percent / 60percent AcOH / Heating

3: CH₂Cl₂ / Ambient temperature

With sodium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/CC9960001073

Reference yield:

: 252272-30-3
(S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol

: 252272-71-2
(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / NaH / tetrahydrofuran / Ambient temperature

2: 99 percent / Bu₄NF / Ambient temperature

3: 76 percent / NBS, PPh₃ / CH₂Cl₂ / Ambient temperature

4: 72 percent / NaH / dimethylformamide / 80 °C

5: 87 percent / 60percent AcOH / Heating

6: CH₂Cl₂ / Ambient temperature

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/CC9960001073