(S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol

Base Information

• Chemical Name: (S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol
• CAS No.: 252272-30-3
• Molecular Formula: C₃₀H₃₄O₃Si
• Molecular Weight: 470.684
• Mol file: 252272-30-3.mol

Synonyms:(S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol

Chemical Property of (S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol

There total 1 articles about (S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-Naphthalenemethanol (1592-38-7) + tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane (106731-74-2,119944-29-5,107033-46-5) → (S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol (252272-30-3)

Guidance literature:

With tropylium tetrafluoroborate; In chloroform; at 70 ℃;

DOI:10.1039/CC9960001073

Reference yield: 97.0%

(S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol (252272-30-3) + methyl iodide (74-88-4) → (S)-1-(t-butyldiphenylsiloxy)-2-methoxy-3-(2-naphthylmethoxy)propane (252272-36-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1039/CC9960001073

Reference yield:

(S)-1-(t-butyldiphenylsiloxy)-3-(2-naphthylmethoxy)-2-propanol (252272-30-3) → (S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester (252272-71-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 97 percent / NaH / tetrahydrofuran / Ambient temperature

2: 99 percent / Bu₄NF / Ambient temperature

3: 76 percent / NBS, PPh₃ / CH₂Cl₂ / Ambient temperature

4: 72 percent / NaH / dimethylformamide / 80 °C

5: 87 percent / 60percent AcOH / Heating

6: CH₂Cl₂ / Ambient temperature

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/CC9960001073

upstream raw materials:

2-Naphthalenemethanol

tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane

Downstream raw materials:

(S)-1-(t-butyldiphenylsiloxy)-2-methoxy-3-(2-naphthylmethoxy)propane

(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-propionic acid benzyl ester

(S)-2-{[1-{5-Benzyloxymethyl-3-[(S)-2-methoxy-3-(naphthalen-2-ylmethoxy)-propoxy]-2-methyl-pyridin-4-yl}-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid benzyl ester