(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

Base Information

Chemical Name:(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide
CAS No.:1443749-20-9
Molecular Formula:C₂₇H₃₀Cl₂FN₃O₃
Molecular Weight:534.458
Hs Code.:

(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

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Chemical Property of (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

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Technology Process of (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

There total 3 articles about (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303605-84-6
C₂₇H₃₀Cl₂FN₃O₃

: 1443749-20-9
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

Guidance literature:: With sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 72h; pH=8 - 9; Inert atmosphere;
DOI:10.1021/jm4005708

Reference yield:

: 1443749-26-5
C₄₁H₄₂Cl₂FN₃O₄

: 1443749-20-9
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / methanol; water / 72 h / 20 °C / pH 8 - 9 / Inert atmosphere

With ammonium cerium (IV) nitrate; sodium hydrogencarbonate; In methanol; water; acetonitrile;
DOI:10.1021/jm4005708

Reference yield:

: 897365-81-0
(3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione

: 1443749-20-9
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-3-hydroxycyclobutyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / methanol; water / 72 h / 20 °C / pH 8 - 9 / Inert atmosphere

With ammonium cerium (IV) nitrate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jm4005708