897365-81-0Relevant articles and documents
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
Ding, Ke,Lu, Yipin,Nikolovska-Coleska, Zaneta,Wang, Guoping,Qiu, Su,Shangary, Sanjeev,Gao, Wei,Qin, Dongguang,Stuckey, Jeanne,Krajewski, Krzysztof,Roller, Peter P.,Wang, Shaomeng
, p. 3432 - 3435 (2006)
Potent, specific, non-peptide small-molecule inhibitors of the MDM2-p53 interaction were successfully designed. The most potent inhibitor (MI-63) has a Ki value of 3 nM binding to MDM2 and greater than 10 000-fold selectivity over Bcl-2/Bcl-xL
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
Zhao, Yujun,Liu, Liu,Sun, Wei,Lu, Jianfeng,McEachern, Donna,Li, Xiaoqin,Yu, Shanghai,Bernard, Denzil,Ochsenbein, Philippe,Ferey, Vincent,Carry, Jean-Christophe,Deschamps, Jeffrey R.,Sun, Duxin,Wang, Shaomeng
, p. 7223 - 7234 (2013/06/27)
Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new
SPIRO-OXINDOLE MDM2 ANTAGONISTS
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, (2012/05/21)
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as
SPIROINDOLINONE PYRROLIDINES
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, (2011/11/12)
There are provided compounds of the formula (I) wherein X, Y and R1 to R8 are as described herein, their enantiomers and pharmaceutically acceptable salts and esters, as well as processes for making these compounds and medicaments containing them.
SPIRO-OXINDOLE MDM2 ANTAGONISTS
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, (2011/05/16)
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as
Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction
Yu, Shanghai,Qin, Dongguang,Shangary, Sanjeev,Chen, Jianyong,Wang, Guoping,Ding, Ke,McEachern, Donna,Qiu, Su,Nikolovska-Coleska, Zaneta,Miller, Rebecca,Kang, Sanmao,Yang, Dajun,Wang, Shaomeng
supporting information; experimental part, p. 7970 - 7973 (2010/06/16)
We report herein the design of potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. Compound 5 binds to MDM2 with a K i of 0.6 nM, activates p53 at concentrations as low as 40 nM, and potently and selectively inhibits