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(3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione

    Cas No: 897365-81-0

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  • (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione

    Cas No: 897365-81-0

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  • 897365-81-0 Structure
  • Basic information

    1. Product Name: (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione
    2. Synonyms: (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione
    3. CAS NO:897365-81-0
    4. Molecular Formula:
    5. Molecular Weight: 643.585
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 897365-81-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione(897365-81-0)
    11. EPA Substance Registry System: (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione(897365-81-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 897365-81-0(Hazardous Substances Data)

897365-81-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 897365-81-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,7,3,6 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 897365-81:
(8*8)+(7*9)+(6*7)+(5*3)+(4*6)+(3*5)+(2*8)+(1*1)=240
240 % 10 = 0
So 897365-81-0 is a valid CAS Registry Number.

897365-81-0Downstream Products

897365-81-0Relevant articles and documents

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction

Ding, Ke,Lu, Yipin,Nikolovska-Coleska, Zaneta,Wang, Guoping,Qiu, Su,Shangary, Sanjeev,Gao, Wei,Qin, Dongguang,Stuckey, Jeanne,Krajewski, Krzysztof,Roller, Peter P.,Wang, Shaomeng

, p. 3432 - 3435 (2006)

Potent, specific, non-peptide small-molecule inhibitors of the MDM2-p53 interaction were successfully designed. The most potent inhibitor (MI-63) has a Ki value of 3 nM binding to MDM2 and greater than 10 000-fold selectivity over Bcl-2/Bcl-xL

Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors

Zhao, Yujun,Liu, Liu,Sun, Wei,Lu, Jianfeng,McEachern, Donna,Li, Xiaoqin,Yu, Shanghai,Bernard, Denzil,Ochsenbein, Philippe,Ferey, Vincent,Carry, Jean-Christophe,Deschamps, Jeffrey R.,Sun, Duxin,Wang, Shaomeng

, p. 7223 - 7234 (2013/06/27)

Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new

SPIRO-OXINDOLE MDM2 ANTAGONISTS

-

, (2012/05/21)

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

SPIROINDOLINONE PYRROLIDINES

-

, (2011/11/12)

There are provided compounds of the formula (I) wherein X, Y and R1 to R8 are as described herein, their enantiomers and pharmaceutically acceptable salts and esters, as well as processes for making these compounds and medicaments containing them.

SPIRO-OXINDOLE MDM2 ANTAGONISTS

-

, (2011/05/16)

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

Yu, Shanghai,Qin, Dongguang,Shangary, Sanjeev,Chen, Jianyong,Wang, Guoping,Ding, Ke,McEachern, Donna,Qiu, Su,Nikolovska-Coleska, Zaneta,Miller, Rebecca,Kang, Sanmao,Yang, Dajun,Wang, Shaomeng

supporting information; experimental part, p. 7970 - 7973 (2010/06/16)

We report herein the design of potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. Compound 5 binds to MDM2 with a K i of 0.6 nM, activates p53 at concentrations as low as 40 nM, and potently and selectively inhibits

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