4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile

Base Information

Chemical Name:4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile
CAS No.:240143-48-0
Molecular Formula:C₁₃H₁₆FN₃
Molecular Weight:233.289
Hs Code.:
DSSTox Substance ID:DTXSID101223785

Synonyms:DTXSID101223785;AKOS012641667;4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile;240143-48-0

Suppliers and Price of 4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:233.13282569
Heavy Atom Count:17
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC#N)CC2=CC=C(C=C2)F

Technology Process of 4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile

There total 3 articles about 4-[(4-Fluorophenyl)methyl]-1-piperazineacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70931-32-7
1-ethoxycarbonyl-4-(4-fluorobenzyl)piperazine

: 240143-48-0
[4-(4-fluoro-benzyl)-piperazin-1-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent HBr / 1 h / Heating

2: K₂CO₃ / acetonitrile

With hydrogen bromide; potassium carbonate; In acetonitrile;
DOI:10.1021/jm981098j

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 240143-48-0
[4-(4-fluoro-benzyl)-piperazin-1-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / acetonitrile / Heating

2: 45 percent HBr / 1 h / Heating

3: K₂CO₃ / acetonitrile

With hydrogen bromide; potassium carbonate; In acetonitrile;
DOI:10.1021/jm981098j