2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether

Base Information

• Chemical Name: 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether
• CAS No.: 115435-87-5
• Molecular Formula: C₁₉H₁₇ClN₄OS
• Molecular Weight: 384.889
• Mol file: 115435-87-5.mol

Synonyms:

Chemical Property of 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether

There total 9 articles about 2-{8-chloro-1-[(methylsulfanyl)methyl]-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl}phenyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl(methylthio)acetic hydrazide (74085-88-4) + 7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione (2890-32-6) → 8-chloro-6-(2-methoxyphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine (115435-87-5)

Guidance literature:

In butan-1-ol; Heating;

Reference yield:

(2-methoxyphenyl)methanol (612-16-8) → 8-chloro-6-(2-methoxyphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine (115435-87-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 82 percent / SOCl₂ / benzene / 1.) 2 deg C, 100 min, 2.) 45-50 deg C, 2 h.

2: 97 percent / dimethylsulfoxide / 3 h / 35 - 45 °C

3: 27 percent / 79percent KOH / benzene; methanol / 1.) 25-32 deg C, 1.5 h, 2.) R_.T_., 3 h.

4: 75 percent / Fe / ethanol; H₂O; acetic acid

5: 99 percent / CHCl₃ / Heating

6: 90 percent / 18percent N₂H₄ / methanol

7: 53 percent / P₂S₅ / pyridine / 0.75 h / Heating

8: 69 percent / butan-1-ol / Heating

With potassium hydroxide; thionyl chloride; tetraphosphorus decasulfide; iron; hydrazine hydrate; In pyridine; methanol; ethanol; chloroform; water; acetic acid; dimethyl sulfoxide; butan-1-ol; benzene;

Reference yield:

2-methoxy-benzeneacetonitrile (7035-03-2) → 8-chloro-6-(2-methoxyphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine (115435-87-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 27 percent / 79percent KOH / benzene; methanol / 1.) 25-32 deg C, 1.5 h, 2.) R_.T_., 3 h.

2: 75 percent / Fe / ethanol; H₂O; acetic acid

3: 99 percent / CHCl₃ / Heating

4: 90 percent / 18percent N₂H₄ / methanol

5: 53 percent / P₂S₅ / pyridine / 0.75 h / Heating

6: 69 percent / butan-1-ol / Heating

With potassium hydroxide; tetraphosphorus decasulfide; iron; hydrazine hydrate; In pyridine; methanol; ethanol; chloroform; water; acetic acid; butan-1-ol; benzene;

upstream raw materials:

ethyl(methylthio)acetic hydrazide

7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione

(2-methoxyphenyl)methanol

2-methoxy-benzeneacetonitrile

Refernces