(R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

Base Information

• Chemical Name: (R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER-HCl
• CAS No.: 279227-92-8
• Molecular Formula: C₁₁H₂₀N₂O₄*ClH
• Molecular Weight: 280.752
• Mol file: 279227-92-8.mol

Synonyms:

Chemical Property of (R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

1-tert-Butyl2-MethylPiperazine-1,2-dicarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

There total 1 articles about (R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester 2-methyl ester (278790-00-4,1313278-42-0) → (R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester hydrochloride (279227-92-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; for 18h;

Reference yield: 95.0%

(R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester hydrochloride (279227-92-8) + di-tert-butyl dicarbonate (24424-99-5) → (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 2-methyl ester (637027-24-8)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 ℃; for 18h;

upstream raw materials:

piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester 2-methyl ester

Downstream raw materials:

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 2-methyl ester

Refernces