kaitocephalin diethylammonium salt

Base Information

• Chemical Name: kaitocephalin diethylammonium salt
• CAS No.: 1010808-39-5
• Molecular Formula: C₄H₁₁N*C₁₈H₂₁Cl₂N₃O₉
• Molecular Weight: 567.423
• Mol file: 1010808-39-5.mol

Synonyms:

Chemical Property of kaitocephalin diethylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of kaitocephalin diethylammonium salt

There total 23 articles about kaitocephalin diethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H47Cl2N3O13 + diethylamine (109-89-7) → kaitocephalin diethylammonium salt (1010808-39-5) + 9-epi-kaitocephalin diethylamine salt

Guidance literature:

C₄₁H₄₇Cl₂N₃O₁₃; With aluminum (III) chloride; dimethylsulfide; at 0 - 20 ℃;

With water; at 0 - 20 ℃;

diethylamine; Further stages;

DOI:10.1021/ol9019343

Reference yield:

C14H25NO4 (1438408-16-2) → kaitocephalin diethylammonium salt (1010808-39-5)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice; Inert atmosphere

2.2: 8 h / 20 °C / Inert atmosphere

2.3: 3.33 h / 20 °C / Inert atmosphere

3.1: C₁₅H₂₆Cl₂CuN₂O₂; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4.1: Dess-Martin periodane / dichloromethane / 5 h / Cooling with ice; Inert atmosphere

5.1: dichloromethane / 15 h / 50 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; mercuric triflate / dichloromethane / 10.5 h / -20 °C / Inert atmosphere; Cooling with ice

6.2: 0.5 h / -78 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

8.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 10.33 h / -40 - -20 °C / Inert atmosphere

9.1: Trimethyl borate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

9.2: 3 h / 50 °C / Inert atmosphere

10.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Cooling with ice; Inert atmosphere

10.2: Inert atmosphere

11.1: hydrogenchloride / methanol / 10 h / 40 °C / Inert atmosphere

11.2: 0.5 h / 0 °C / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

12.2: 0 - 20 °C / Inert atmosphere

13.1: [bis(acetoxy)iodo]benzene; 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl / aq. phosphate buffer; acetonitrile / 8 h / 20 °C / pH 6.8 / Inert atmosphere

13.2: 3 h / 20 °C / pH 2 / Inert atmosphere

14.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen / chloroform / 2 h / 20 °C

14.2: Dowex? 50WX4 (H⁺)

15.1: COSMOSIL 75C₁₈-OPN / aq. buffer / pH 7

With 1H-imidazole; hydrogenchloride; 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl; Trimethyl borate; [bis(acetoxy)iodo]benzene; 20 wt.% Pd(OH)2 on activated carbon; C₁₅H₂₆Cl₂CuN₂O₂; hydrogen; iodine; mercuric triflate; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; methanol; aq. phosphate buffer; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil; 4.1: |Dess-Martin Oxidation / 5.1: |Wittig Olefination;

DOI:10.1039/c3cc42365d

Reference yield:

C14H24INO3 (1438408-17-3) → kaitocephalin diethylammonium salt (1010808-39-5)

Guidance literature:

Multi-step reaction with 14 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere

1.3: 3.33 h / 20 °C / Inert atmosphere

2.1: C₁₅H₂₆Cl₂CuN₂O₂; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 5 h / Cooling with ice; Inert atmosphere

4.1: dichloromethane / 15 h / 50 °C / Inert atmosphere

5.1: sodium hydrogencarbonate; mercuric triflate / dichloromethane / 10.5 h / -20 °C / Inert atmosphere; Cooling with ice

5.2: 0.5 h / -78 °C / Inert atmosphere

6.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

7.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 10.33 h / -40 - -20 °C / Inert atmosphere

8.1: Trimethyl borate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

8.2: 3 h / 50 °C / Inert atmosphere

9.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Cooling with ice; Inert atmosphere

9.2: Inert atmosphere

10.1: hydrogenchloride / methanol / 10 h / 40 °C / Inert atmosphere

10.2: 0.5 h / 0 °C / Inert atmosphere

11.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

11.2: 0 - 20 °C / Inert atmosphere

12.1: [bis(acetoxy)iodo]benzene; 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl / aq. phosphate buffer; acetonitrile / 8 h / 20 °C / pH 6.8 / Inert atmosphere

12.2: 3 h / 20 °C / pH 2 / Inert atmosphere

13.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen / chloroform / 2 h / 20 °C

13.2: Dowex? 50WX4 (H⁺)

14.1: COSMOSIL 75C₁₈-OPN / aq. buffer / pH 7

With hydrogenchloride; 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl; Trimethyl borate; [bis(acetoxy)iodo]benzene; 20 wt.% Pd(OH)2 on activated carbon; C₁₅H₂₆Cl₂CuN₂O₂; hydrogen; mercuric triflate; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; aq. phosphate buffer; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil; 3.1: |Dess-Martin Oxidation / 4.1: |Wittig Olefination;

DOI:10.1039/c3cc42365d

upstream raw materials:

diethylamine

C₁₄H₂₅NO₄

C₁₄H₂₄INO₃

C₂₅H₃₈N₂O₇