(S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate

Base Information

Chemical Name:(S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate
CAS No.:1334483-05-4
Molecular Formula:C₂₀H₃₀N₂O₄
Molecular Weight:362.469
Hs Code.:

Synonyms:

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Chemical Property of (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate

Chemical Property:

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Technology Process of (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate

There total 5 articles about (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 660862-47-5
(S)-2-(piperazin-2-yl)ethan-1-ol

: 1334483-05-4
(S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 65 - 75 °C / Inert atmosphere; Large scale reaction

1.2: 4 h / 20 °C / Inert atmosphere; Large scale reaction

2.1: tetrahydrofuran / 48 h / 50 - 60 °C / Inert atmosphere; Large scale reaction

With triethylamine; In tetrahydrofuran; 2.1: Michael addition;
DOI:10.1021/op2001854

Reference yield:

: 52661-95-7
(S)-ethyl 2-(3,6-dioxopiperazin-2-yl)acetate

: 1334483-05-4
(S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 20 - 50 °C / Inert atmosphere; Large scale reaction

1.2: 4.25 h / 40 - 50 °C / Inert atmosphere; Large scale reaction

2.1: triethylamine / 65 - 75 °C / Inert atmosphere; Large scale reaction

2.2: 4 h / 20 °C / Inert atmosphere; Large scale reaction

3.1: tetrahydrofuran / 48 h / 50 - 60 °C / Inert atmosphere; Large scale reaction

With lithium borohydride; triethylamine; In tetrahydrofuran; 3.1: Michael addition;
DOI:10.1021/op2001854

Reference yield:

: C₁₅H₂₆N₂O₇

: 1334483-05-4
(S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid / ethanol / 1 h / 60 - 70 °C / Inert atmosphere; Large scale reaction

1.2: 5 h / Inert atmosphere; Reflux; Large scale reaction

2.1: lithium borohydride / tetrahydrofuran / 20 - 50 °C / Inert atmosphere; Large scale reaction

2.2: 4.25 h / 40 - 50 °C / Inert atmosphere; Large scale reaction

3.1: triethylamine / 65 - 75 °C / Inert atmosphere; Large scale reaction

3.2: 4 h / 20 °C / Inert atmosphere; Large scale reaction

4.1: tetrahydrofuran / 48 h / 50 - 60 °C / Inert atmosphere; Large scale reaction

With lithium borohydride; methanesulfonic acid; triethylamine; In tetrahydrofuran; ethanol; 4.1: Michael addition;
DOI:10.1021/op2001854