C₄₆H₆₃NO₁₅

Base Information

• Chemical Name: C₄₆H₆₃NO₁₅
• CAS No.: 942950-93-8
• Molecular Formula: C₄₆H₆₃NO₁₅
• Molecular Weight: 870.004
• Mol file: 942950-93-8.mol

Synonyms:

Chemical Property of C₄₆H₆₃NO₁₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₆H₆₃NO₁₅

There total 10 articles about C₄₆H₆₃NO₁₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-deacetylbaccatin III (32981-86-5,172018-16-5) → C46H63NO15 (849213-17-8) + C46H63NO15 (942950-93-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: n-hexyllithium / tetrahydrofuran / 2 h / -44 - -39 °C / Neslab chiller

1.2: 10 °C

2.1: dmap; dicyclohexyl-carbodiimide / toluene / 51 °C

3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / tetrahydrofuran; water / 66 h

4.1: triethylamine / dmap / dichloromethane / 6 h

5.1: 4-methylmorpholine N-oxide; sodium sulfate / dichloromethane / 1 h

5.2: 17.75 h / Molecular sieve

6.1: sodium tetrahydroborate / methanol; ethanol / 3 h / 0 °C

7.1: triethylamine / dmap / dichloromethane / 19 h

8.1: camphor-10-sulfonic acid / methanol; dichloromethane / 4 h / 20 °C

9.1: camphor-10-sulfonic acid / dichloromethane / 3.5 h / 20 °C

10.1: n-heptane; tert-butyl methyl ether / Resolution of racemate

With hydrogenchloride; dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; hydrogen; n-hexyllithium; 4-methylmorpholine N-oxide; sodium sulfate; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; tert-butyl methyl ether; water; toluene;

Reference yield:

C41H57NO14 (849213-20-3) → C46H63NO15 (849213-17-8) + C46H63NO15 (942950-93-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / dmap / dichloromethane / 6 h

2.1: 4-methylmorpholine N-oxide; sodium sulfate / dichloromethane / 1 h

2.2: 17.75 h / Molecular sieve

3.1: sodium tetrahydroborate / methanol; ethanol / 3 h / 0 °C

4.1: triethylamine / dmap / dichloromethane / 19 h

5.1: camphor-10-sulfonic acid / methanol; dichloromethane / 4 h / 20 °C

6.1: camphor-10-sulfonic acid / dichloromethane / 3.5 h / 20 °C

7.1: n-heptane; tert-butyl methyl ether / Resolution of racemate

With sodium tetrahydroborate; camphor-10-sulfonic acid; 4-methylmorpholine N-oxide; sodium sulfate; triethylamine; dmap; In methanol; ethanol; n-heptane; dichloromethane; tert-butyl methyl ether;

Reference yield:

C53H83NO14Si2 (849213-22-5) → C46H63NO15 (849213-17-8) + C46H63NO15 (942950-93-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol; ethanol / 3 h / 0 °C

2: triethylamine / dmap / dichloromethane / 19 h

3: camphor-10-sulfonic acid / methanol; dichloromethane / 4 h / 20 °C

4: camphor-10-sulfonic acid / dichloromethane / 3.5 h / 20 °C

5: n-heptane; tert-butyl methyl ether / Resolution of racemate

With sodium tetrahydroborate; camphor-10-sulfonic acid; triethylamine; dmap; In methanol; ethanol; n-heptane; dichloromethane; tert-butyl methyl ether;

upstream raw materials:

TPI 287

C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III

10-deacetylbaccatin III

C₄₁H₅₇NO₁₄