C₁₇H₁₄ClN₃O

Base Information

• Chemical Name: C₁₇H₁₄ClN₃O
• CAS No.: 1492906-24-7
• Molecular Formula: C₁₇H₁₄ClN₃O
• Molecular Weight: 311.771
• Mol file: 1492906-24-7.mol

Synonyms:

Chemical Property of C₁₇H₁₄ClN₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₄ClN₃O

There total 7 articles about C₁₇H₁₄ClN₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-(1-cyanocyclobutyl)phenyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile (1236409-72-5) → C17H14ClN3O (1492906-24-7)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 10 - 20 ℃;

DOI:10.1021/op400215h

Reference yield:

1-(4-aminophenyl)cyclobutanecarbonitrile (811803-25-5) → C17H14ClN3O (1492906-24-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid / 48 h / 60 °C / Large scale

2.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tert-butyl methyl ether; ethyl acetate / 23 h / -5 - 20 °C / Large scale

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 60 °C / Large scale

3.2: 20 h / 20 - 30 °C / pH 1 - 2 / Large scale

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 10 - 20 °C

With oxalyl dichloride; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; ethyl acetate;

DOI:10.1021/op400215h

Reference yield:

1-phenylcyclobutanecarbonitrile (14377-68-5) → C17H14ClN3O (1492906-24-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium nitrate; sulfuric acid / 0 °C

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 60 °C / 2327.23 - 2585.81 Torr

3.1: acetic acid / 48 h / 60 °C / Large scale

4.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tert-butyl methyl ether; ethyl acetate / 23 h / -5 - 20 °C / Large scale

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 60 °C / Large scale

5.2: 20 h / 20 - 30 °C / pH 1 - 2 / Large scale

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 10 - 20 °C

With oxalyl dichloride; sulfuric acid; 5%-palladium/activated carbon; hydrogen; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium nitrate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; ethyl acetate;

DOI:10.1021/op400215h

upstream raw materials:

1-(4-aminophenyl)cyclobutanecarbonitrile

1-phenylcyclobutanecarbonitrile

ethyl 3-(4-(1-cyanocyclobutyl)phenylamino)propanoate

4-Nitrophenylacetonitrile

Downstream raw materials:

C₁₈H₁₅N₅O

1-(4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-phenyl)cyclobutanecarbonitrile

1-(4-(1-cyanocyclobutyl)phenyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile

Refernces