Technology Process of (4SR,5RS)-4-butyl-2,2-dimethyl-5-phenyl-5-(trimethylsilyl)oxy-3-pentanone
There total 4 articles about (4SR,5RS)-4-butyl-2,2-dimethyl-5-phenyl-5-(trimethylsilyl)oxy-3-pentanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 54 percent / pyridinium chlorochromate / CH2Cl2 / 11 h
2: 1.) lithium diisopropylamine / 1.) pentane, room temp., 30 min, 2.) room temp., 7.5 h
3: 75 percent / 48 h / 90 °C
With
pyridinium chlorochromate; lithium diisopropyl amide;
In
dichloromethane;
DOI:10.1021/jo00171a035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / diethyl ether; pentane / 1.) -78 deg C, 1 h, 2.) room temp., 2.5 h
2: 54 percent / pyridinium chlorochromate / CH2Cl2 / 11 h
3: 1.) lithium diisopropylamine / 1.) pentane, room temp., 30 min, 2.) room temp., 7.5 h
4: 75 percent / 48 h / 90 °C
With
pyridinium chlorochromate; lithium diisopropyl amide;
In
diethyl ether; dichloromethane; pentane;
DOI:10.1021/jo00171a035
