C₂₈H₂₁NO₅

Base Information

• Chemical Name: C₂₈H₂₁NO₅
• CAS No.: 133165-24-9
• Molecular Formula: C₂₈H₂₁NO₅
• Molecular Weight: 451.478
• Mol file: 133165-24-9.mol

Synonyms:

Chemical Property of C₂₈H₂₁NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₁NO₅

There total 12 articles about C₂₈H₂₁NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + C26H19NO4 (130031-63-9) → C28H21NO5 (133165-24-9,141395-33-7)

Guidance literature:

With pyridine; dmap; at 25 ℃; for 2h;

DOI:10.1021/ja00008a045

Reference yield:

7,8,9,10-tetrahydrophenanthridine (62833-92-5) → C28H21NO5 (133165-24-9,141395-33-7)

Guidance literature:

Multi-step reaction with 12 steps

1: 78 percent / mCPBA / CH₂Cl₂ / 1 h / 25 °C

2: 87 percent / 20 h / 100 °C

3: 100 percent / K₂CO₃ / methanol / 1 h / 25 °C

4: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5: 1.) THF, -78 degC to 0 deg C, 2.) -78 deg C to 25 deg C, 1 h

6: 85 percent / mCPBA / CH₂Cl₂ / 2 h / 25 °C

7: 100 percent / Bu₄NF / tetrahydrofuran / 3 h / 42 °C

8: 80 percent / pyridinium chlorochromate, 4-Angstroem molecular sieves / CH₂Cl₂ / 1 h / 25 °C

9: 1.) Pd(CH₃COO)2, Ph₃P, n-BuNH₂, 2.) Cu₂I₂ / 1.) C₆H₆, 25 deg C, 15 min, 2.) 25 deg C, 2 h

10: 1.) AgNO₃, 2.) KCN / 1.) H₂O, C₂H₅OH, THF, 25 deg C, 5 min, 2.) 10 min

11: 59 percent / LDA / toluene; cyclohexane / 1 h / -78 °C

12: 100 percent / pyridine, 4-(dimethylamino)pyridine / 2 h / 25 °C

With pyridine; 2,6-dimethylpyridine; dmap; potassium cyanide; palladium diacetate; copper (I) iodide; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; silver nitrate; N-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; toluene;

DOI:10.1021/ja00008a045

Reference yield:

7,8,9,10-tetrahydrophenanthridine N-oxide (133165-23-8) → C28H21NO5 (133165-24-9,141395-33-7)

Guidance literature:

Multi-step reaction with 11 steps

1: 87 percent / 20 h / 100 °C

2: 100 percent / K₂CO₃ / methanol / 1 h / 25 °C

3: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

4: 1.) THF, -78 degC to 0 deg C, 2.) -78 deg C to 25 deg C, 1 h

5: 85 percent / mCPBA / CH₂Cl₂ / 2 h / 25 °C

6: 100 percent / Bu₄NF / tetrahydrofuran / 3 h / 42 °C

7: 80 percent / pyridinium chlorochromate, 4-Angstroem molecular sieves / CH₂Cl₂ / 1 h / 25 °C

8: 1.) Pd(CH₃COO)2, Ph₃P, n-BuNH₂, 2.) Cu₂I₂ / 1.) C₆H₆, 25 deg C, 15 min, 2.) 25 deg C, 2 h

9: 1.) AgNO₃, 2.) KCN / 1.) H₂O, C₂H₅OH, THF, 25 deg C, 5 min, 2.) 10 min

10: 59 percent / LDA / toluene; cyclohexane / 1 h / -78 °C

11: 100 percent / pyridine, 4-(dimethylamino)pyridine / 2 h / 25 °C

With pyridine; 2,6-dimethylpyridine; dmap; potassium cyanide; palladium diacetate; copper (I) iodide; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; silver nitrate; N-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; toluene;

DOI:10.1021/ja00008a045

upstream raw materials:

acetic anhydride

C₂₆H₁₉NO₄

7,8,9,10-tetrahydrophenanthridine

7,8,9,10-tetrahydrophenanthridine N-oxide

Downstream raw materials:

C₂₈H₂₅NO₆

C₂₈H₂₄ClNO₅