Suc-Leu-Phe-BPP

Base Information

• Chemical Name: Suc-Leu-Phe-BPP
• CAS No.: 123068-59-7
• Molecular Formula: C₃₁H₄₁N₃O₅
• Molecular Weight: 535.684
• Mol file: 123068-59-7.mol

Synonyms:

Chemical Property of Suc-Leu-Phe-BPP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Suc-Leu-Phe-BPP

There total 7 articles about Suc-Leu-Phe-BPP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

succinic acid anhydride (108-30-5) + H-L-Leu-L-Phe-BPP*HCl (123068-85-9,123068-94-0) → Suc-Leu-Phe-BPP (123068-59-7)

Guidance literature:

With triethylamine; In pyridine; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.36.4794

Reference yield:

4-benzylpyperidine (31252-42-3) → Suc-Leu-Phe-BPP (123068-59-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 72 percent / tetrahydrofuran / 4 °C

2: 3.5N HCl / dioxane

3: 89 percent / HOBt, Et₃N, DCC / dimethylformamide / 4 °C

4: 3.5N HCl / dioxane

5: 61 percent / Et₃N / pyridine / 1.5 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.4794

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Suc-Leu-Phe-BPP (123068-59-7)

Guidance literature:

Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran

2: 72 percent / tetrahydrofuran / 4 °C

3: 3.5N HCl / dioxane

4: 89 percent / HOBt, Et₃N, DCC / dimethylformamide / 4 °C

5: 3.5N HCl / dioxane

6: 61 percent / Et₃N / pyridine / 1.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.4794

upstream raw materials:

succinic acid anhydride

H-L-Leu-L-Phe-BPP*HCl

4-benzylpyperidine

N-tert-butoxycarbonyl-L-phenylalanine