(2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Base Information

• Chemical Name: (2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester
• CAS No.: 72619-18-2
• Molecular Formula: C₁₆H₁₅NO₆
• Molecular Weight: 317.298
• Mol file: 72619-18-2.mol

Synonyms:

Chemical Property of (2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

There total 2 articles about (2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-Pentadiene (591-93-5) → (2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester (72619-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 16.05 g / 72 h / Ambient temperature

2: 1.) 4 Angstroem sieves, 2.) potassium carbonate / 1) DMF, 6 h; 2) room temperature

With 4 A molecular sieve; potassium carbonate;

DOI:10.1039/P19810003242

Reference yield:

3-Bromophthalide (6940-49-4) + 4-allylazetidin-2-one (68485-52-9) + Glyoxilic acid (298-12-4) → (2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester (72619-18-2)

Guidance literature:

With 4 A molecular sieve; potassium carbonate; Yield given. Multistep reaction; 1) DMF, 6 h; 2) room temperature;

DOI:10.1039/P19810003242

Reference yield:

(2-Allyl-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester (72619-18-2) → phthalidyl (4-allyl-2-oxoazetidin-1-yl)-tris-(p-methoxyphenyl)phosphoranylideneacetate (68486-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 2,6-lutidine, 2.) thionyl chloride / 1) -20 deg C, THF; 2) 0 deg C, 30 min

2: 6.25 g / 2,6-lutidine / dioxane / Ambient temperature

With 2,6-dimethylpyridine; thionyl chloride; In 1,4-dioxane;

DOI:10.1039/P19810003242

upstream raw materials:

3-Bromophthalide

4-allylazetidin-2-one

Glyoxilic acid

1,4-Pentadiene

Downstream raw materials:

phthalidyl (4-allyl-2-oxoazetidin-1-yl)-tris-(p-methoxyphenyl)phosphoranylideneacetate