Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

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Chemical Name:Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine
CAS No.:140654-86-0
Molecular Formula:C₉H₁₆N₂*C₂₉H₂₇N₅O₅S
Molecular Weight:709.869
Hs Code.:

Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

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Chemical Property of Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

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Technology Process of Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

There total 4 articles about Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 140654-84-8
(1R,5S,6S)-6-Trityloxymethyl-2,4-dioxa-3-thia-bicyclo[3.2.0]heptane 3,3-dioxide

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 73-24-5,71660-29-2,71660-30-5
7H-purin-6-ylamine

: 140654-86-0
Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

Guidance literature:: In dimethyl sulfoxide; at 50 ℃; for 1h;
DOI:10.1016/S0957-4166(00)80187-1

Reference yield:

: 140654-76-8
C₂₄H₂₂O

: 140654-86-0
Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

Guidance literature:: Multi-step reaction with 4 steps

1: OsO₄, N-methyl-morpholine-N-oxide

3: 1.) SOCl₂, Et₃N, 2.) dimethyldioxirane

4: 73 percent / dimethylsulfoxide / 1 h / 50 °C

With osmium(VIII) oxide; thionyl chloride; 3,3-dimethyldioxirane; 4-methylmorpholine N-oxide; triethylamine; In dimethyl sulfoxide;
DOI:10.1016/S0957-4166(00)80187-1

Reference yield:

: 140654-83-7,140696-44-2,140696-45-3
(1R,2S,3S)-3-Trityloxymethyl-cyclobutane-1,2-diol

: 140654-86-0
Sulfuric acid mono-[(1S,2S,4S)-2-(6-amino-purin-9-yl)-4-trityloxymethyl-cyclobutyl] ester; compound with 2,3,4,6,7,8,9,10-octahydro-pyrimido[1,2-a]azepine

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) SOCl₂, Et₃N, 2.) dimethyldioxirane

3: 73 percent / dimethylsulfoxide / 1 h / 50 °C

With thionyl chloride; 3,3-dimethyldioxirane; triethylamine; In dimethyl sulfoxide;
DOI:10.1016/S0957-4166(00)80187-1