6-Episedacrine

Base Information

Chemical Name:6-Episedacrine
CAS No.:92471-52-8
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:

Synonyms:

Suppliers and Price of 6-Episedacrine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Episedacrine

Chemical Property:

Purity/Quality:

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Technology Process of 6-Episedacrine

There total 22 articles about 6-Episedacrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76469-99-3
1-(carbomethoxy)-2-phenacylpiperidine

: 61550-92-3,92471-52-8,134107-83-8,134107-84-9
Episedacrine / Sedacrine

Guidance literature:: Multi-step reaction with 10 steps

1: Li(tBuO)3AlH / tetrahydrofuran / 4 h / Heating

2: 100 percent / pyridine / 15 h / Ambient temperature

3: 343 mg / Et₄NOTs / 0.17 h / anodic methoxylation

4: 1) TiCl₄ / 1) CH₂Cl₂, -78 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 2h, then to r.t., 2h

5: 85 percent / Na, I₂ / 1 h

6: 43 percent / DBU / toluene / 4 h / 87 °C

7: 1) TiCl₄ / 1) CH₂Cl₂, -78 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 2h, to r.t. 2h

8: 64 mg / TsOH*H₂O / benzene / 16 h / Heating

9: 86 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

10: 32 mg / 0.1N aq. HCl / 0.5 h / Heating

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; iodine; sodium; titanium tetrachloride; tetraethylammonium tosylate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; toluene; benzene;
DOI:10.1139/v91-034

Reference yield:

: 134040-02-1,134040-03-2
(R)-2-((R)-2-Hydroxy-2-phenyl-ethyl)-piperidine-1-carboxylic acid methyl ester

: 61550-92-3,92471-52-8,134107-83-8,134107-84-9
Episedacrine / Sedacrine

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / pyridine / 15 h / Ambient temperature

2: 343 mg / Et₄NOTs / 0.17 h / anodic methoxylation

3: 1) TiCl₄ / 1) CH₂Cl₂, -78 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 2h, then to r.t., 2h

4: 85 percent / Na, I₂ / 1 h

5: 43 percent / DBU / toluene / 4 h / 87 °C

6: 1) TiCl₄ / 1) CH₂Cl₂, -78 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 2h, to r.t. 2h

7: 64 mg / TsOH*H₂O / benzene / 16 h / Heating

8: 86 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

9: 32 mg / 0.1N aq. HCl / 0.5 h / Heating

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; iodine; sodium; titanium tetrachloride; tetraethylammonium tosylate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene; benzene;
DOI:10.1139/v91-034

Reference yield:

: 134040-05-4
(R)-2-((R)-2-Acetoxy-2-phenyl-ethyl)-6-methoxy-piperidine-1-carboxylic acid methyl ester

: 61550-92-3,92471-52-8,134107-83-8,134107-84-9
Episedacrine / Sedacrine

Guidance literature:: Multi-step reaction with 7 steps

1: 1) TiCl₄ / 1) CH₂Cl₂, -78 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 2h, then to r.t., 2h

2: 85 percent / Na, I₂ / 1 h

3: 43 percent / DBU / toluene / 4 h / 87 °C

4: 1) TiCl₄ / 1) CH₂Cl₂, -78 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 2h, to r.t. 2h

5: 64 mg / TsOH*H₂O / benzene / 16 h / Heating

6: 86 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

7: 32 mg / 0.1N aq. HCl / 0.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; iodine; sodium; titanium tetrachloride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene; benzene;
DOI:10.1139/v91-034