Technology Process of C25H26FN5O
There total 4 articles about C25H26FN5O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hexamethyldisilazane; hydrazine / tetrahydrofuran
2: trichlorophosphate
3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux
With
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; lithium hexamethyldisilazane; hydrazine; trichlorophosphate;
In
tetrahydrofuran; toluene;
3: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trichlorophosphate
2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux
With
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trichlorophosphate;
In
toluene;
2: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 8-quinolinol; copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 110 °C
2: lithium hexamethyldisilazane; hydrazine / tetrahydrofuran
3: trichlorophosphate
4: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux
With
copper(l) iodide; 8-quinolinol; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; lithium hexamethyldisilazane; hydrazine; trichlorophosphate;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
4: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143