Technology Process of 1-(2'-deoxy-2',2''-dideuterio-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-methyl-1H,3H-pyrimidine-2,4-dione
There total 10 articles about 1-(2'-deoxy-2',2''-dideuterio-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-methyl-1H,3H-pyrimidine-2,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 94 percent / lithium aluminium deuteride / tetrahydrofuran / 1.) 15 min., 0 deg C, 2.) 3 h. room temp.
3: 79 percent / tributyltin deuteride / toluene / 23 h / Heating
4: 80 percent / 80percent acetic acid / 24 h / Ambient temperature
5: 93 percent / hydrogen chloride / 36 h / Ambient temperature
6: 1.) 1percent hydrogen chloride / 1.) 15 min., 2.) 0 deg C, 1 h.
7: 83.5 percent / presaturated glacial acetic acid, dry hydrogen chloride / acetic acid / 1.) room temp., 2.) 0 deg C, 30 min.
8: 1.) hexamethyldisilazane, trimethylchlorosilane / 1.) reflux, 2.) chloroform, 24 h., room temp.
With
hydrogenchloride; chloro-trimethyl-silane; lithium aluminium deuteride; presaturated glacial acetic acid; tributyltin deuteride; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; acetic acid; toluene;
DOI:10.1016/S0040-4020(01)86822-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) 1percent hydrogen chloride / 1.) 15 min., 2.) 0 deg C, 1 h.
2: 83.5 percent / presaturated glacial acetic acid, dry hydrogen chloride / acetic acid / 1.) room temp., 2.) 0 deg C, 30 min.
3: 1.) hexamethyldisilazane, trimethylchlorosilane / 1.) reflux, 2.) chloroform, 24 h., room temp.
With
hydrogenchloride; chloro-trimethyl-silane; presaturated glacial acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetic acid;
DOI:10.1016/S0040-4020(01)86822-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / hydrogen chloride / 36 h / Ambient temperature
2: 1.) 1percent hydrogen chloride / 1.) 15 min., 2.) 0 deg C, 1 h.
3: 83.5 percent / presaturated glacial acetic acid, dry hydrogen chloride / acetic acid / 1.) room temp., 2.) 0 deg C, 30 min.
4: 1.) hexamethyldisilazane, trimethylchlorosilane / 1.) reflux, 2.) chloroform, 24 h., room temp.
With
hydrogenchloride; chloro-trimethyl-silane; presaturated glacial acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetic acid;
DOI:10.1016/S0040-4020(01)86822-8
