(1'S,2S,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine

Base Information

• Chemical Name: (1'S,2S,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine
• CAS No.: 123122-69-0
• Molecular Formula: C₃₁H₄₂N₂O
• Molecular Weight: 458.687
• Mol file: 123122-69-0.mol

Synonyms:

Chemical Property of (1'S,2S,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S,2S,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine

There total 5 articles about (1'S,2S,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-valinol (2026-48-4,473-75-6) → (1'S,2S,3R)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine (123122-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / acetic acid (pH ca. 6), sodium cyanoborohydride / methanol / 16 h / Ambient temperature

2: 80 percent / neat (no solvent) / 16 h / 50 °C

3: diethyl ether / 1.5 h / 0 - 20 °C

With sodium cyanoborohydride; acetic acid; In methanol; diethyl ether;

DOI:10.1021/jo00284a032

Reference yield:

benzaldehyde (100-52-7) → (1'S,2S,3R)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine (123122-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / acetic acid (pH ca. 6), sodium cyanoborohydride / methanol / 16 h / Ambient temperature

2: 80 percent / neat (no solvent) / 16 h / 50 °C

3: diethyl ether / 1.5 h / 0 - 20 °C

With sodium cyanoborohydride; acetic acid; In methanol; diethyl ether;

DOI:10.1021/jo00284a032

Reference yield:

ethylmagnesium bromide (925-90-6) + (1'S,2S,4S)-3-benzyl-2-<1'-(dibenzylamino)ethyl>-4-(methylethyl)-1,3-oxazolidine (123054-05-7) → (1'S,2S,3R)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine (123122-69-0) + (1'S,2S,3S)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-2,3-pentanediamine (123054-07-9)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 1.5h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00284a032

upstream raw materials:

ethylmagnesium bromide

(1'S,2S,4S)-3-benzyl-2-<1'-(dibenzylamino)ethyl>-4-(methylethyl)-1,3-oxazolidine

(S)-valinol

N-benzyl-L-valinol

Downstream raw materials:

Boc-AlaΨVal-Phe-OMe

Refernces