tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

Base Information

Chemical Name:tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate
CAS No.:1242457-01-7
Molecular Formula:C₃₅H₄₃N₃O₅
Molecular Weight:585.744
Hs Code.:

tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

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Chemical Property of tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

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Technology Process of tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

There total 7 articles about tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242456-99-0
tert-butyl cis/trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

: 1242457-01-7,1242457-25-5
tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

Guidance literature:: With formic acid; In water; acetonitrile; at 35 ℃; Resolution of racemate;

Reference yield:

: tert-butyl cis/trans-1-[4-aminobut-2-en-1-yl]cyclopropanecarboxylate

: (+)-cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetic acid

: tert-butyl cis-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

: 1242457-01-7,1242457-25-5
tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 613-94-5
benzoic acid hydrazide

: tert-butyl cis-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

: 1242457-01-7,1242457-25-5
tert-butyl trans-1-[4-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-2-en-1-yl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 0.5 h / Reflux

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 100 °C

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4: trifluoroacetic acid / dichloromethane

5: chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide) / ethyl acetate; 2-Methylpentane / 24 °C / Resolution of racemate

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 2-Methylpentane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;