Technology Process of 4-(1,3-dioxoisoindolin-2-yl)-2-(phenylsulfonyl)butanal
There total 3 articles about 4-(1,3-dioxoisoindolin-2-yl)-2-(phenylsulfonyl)butanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dilauryl peroxide;
In
ethyl acetate;
for 6h;
Inert atmosphere;
Reflux;
DOI:10.1021/ja400831w
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2: dilauryl peroxide / ethyl acetate / 6 h / Inert atmosphere; Reflux
With
dilauryl peroxide; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; ethyl acetate;
DOI:10.1021/ja400831w
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 0.58 h / -78 - 20 °C / Inert atmosphere
1.2: 1.5 h / -78 - 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3.1: dilauryl peroxide / ethyl acetate / 6 h / Inert atmosphere; Reflux
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; dilauryl peroxide; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja400831w