(S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester
• CAS No.: 201995-97-3
• Molecular Formula: C₃₈H₅₅N₃O₈Si
• Molecular Weight: 709.955

Synonyms:

Chemical Property of (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester

There total 6 articles about (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-[(4S,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-6,8-dimethoxy-4,10-dimethyl-3-oxo-7-trimethylsilanyloxy-undecanoyl]-piperidine-2-carboxylic acid methyl ester (201995-96-2) → (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester (201995-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HOAc / tetrahydrofuran; H₂O

2: HO₂C-C₆H₄-SO₂N₃, Et₃N

With HO₂C-C₆H₄-SO₂N₃; acetic acid; triethylamine; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(97)10533-0

Reference yield:

dilithium salt of N-acetyl-L-pipecolic acid → (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester (201995-97-3)

Guidance literature:

Multi-step reaction with 2 steps

2: HO₂C-C₆H₄-SO₂N₃, Et₃N

With HO₂C-C₆H₄-SO₂N₃; triethylamine;

DOI:10.1016/S0040-4039(97)10533-0

Reference yield:

(S)-1-(2-{(2S,3R,5S,6R)-6-[(1S,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-3-methyl-butyl]-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl}-acetyl)-piperidine-2-carboxylic acid methyl ester (201995-87-1) → (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester (201995-97-3)

Guidance literature:

With HO₂C-C₆H₄-SO₂N₃; triethylamine;

DOI:10.1016/S0040-4039(97)10533-0

upstream raw materials:

(S)-1-(2-{(2S,3R,5S,6R)-6-[(1S,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-3-methyl-butyl]-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl}-acetyl)-piperidine-2-carboxylic acid methyl ester

tert-butylchlorodiphenylsilane

(S)-1-[(4S,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-6,8-dimethoxy-4,10-dimethyl-3-oxo-7-trimethylsilanyloxy-undecanoyl]-piperidine-2-carboxylic acid methyl ester

(S)-1-(2-{(2S,3S,5S,6R)-6-[(1S,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-3-methyl-butyl]-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl}-acetyl)-piperidine-2-carboxylic acid methyl ester

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