IQ-1 sodium

Base Information

• Chemical Name: IQ-1 sodium
• CAS No.: 23146-22-7
• Molecular Formula: C₁₅H₉N₃O
• Molecular Weight: 247.256
• Hs Code.: 2933998090
• Mol file: 23146-22-7.mol

Synonyms:

Chemical Property of IQ-1 sodium

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble2mg/mL, clear (warmed)

Purity/Quality:

99.3% ^*data from raw suppliers

IQ-1S ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: IQ 1S is a JNK inhibitor which inhibits LPS-induced proinflammatory.

Technology Process of IQ-1 sodium

There total 4 articles about IQ-1 sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

11H-Indeno[1,2-b]quinoxaline-11-one (6954-91-2) → 11H-indeno[1,2-b]quinoxalin-11-one oxime (23146-22-7)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2015.11.031

Reference yield:

indan-1,2,3-trione hydrate (485-47-2) → 11H-indeno[1,2-b]quinoxalin-11-one oxime (23146-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: hydroxylamine hydrochloride / ethanol / 6 h / Reflux

With hydroxylamine hydrochloride; In ethanol;

DOI:10.1016/j.ejmech.2015.11.031

Reference yield:

1,2-diamino-benzene (95-54-5) → 11H-indeno[1,2-b]quinoxalin-11-one oxime (23146-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: hydroxylamine hydrochloride / ethanol / 6 h / Reflux

With hydroxylamine hydrochloride; In ethanol;

DOI:10.1016/j.ejmech.2015.11.031

upstream raw materials:

11H-Indeno[1,2-b]quinoxaline-11-one

indan-1,2,3-trione hydrate

1,2-diamino-benzene

Refernces

• 1、 Otomasu,Omiya. "Synthesis of condensed quinoxalines. I. On the reaction of 11-oxo-11H-indeno[1,2-b]quinoxaline". . p. 607 - 609. Retrieved 2007/10/04.