7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
• CAS No.: 474410-80-5
• Molecular Formula: C₂₇H₂₆FN₃O₄
• Molecular Weight: 475.52
• Mol file: 474410-80-5.mol

Synonyms:

Chemical Property of 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

There total 7 articles about 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-fluorobenzyl bromide (446-48-0) → 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester (474410-80-5)

Guidance literature:

Multi-step reaction with 3 steps

1: TBAF / tetrahydrofuran

2: H₂ / Pd/C / acetic acid / 1551.44 Torr

3: Et₃N / tetrahydrofuran

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid;

DOI:10.1016/S0960-894X(01)00780-6

Reference yield:

ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate (53135-24-3) → 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester (474410-80-5)

Guidance literature:

Multi-step reaction with 5 steps

1: TBAF / tetrahydrofuran

2: NaH / tetrahydrofuran

3: TBAF / tetrahydrofuran

4: H₂ / Pd/C / acetic acid / 1551.44 Torr

5: Et₃N / tetrahydrofuran

With tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid;

DOI:10.1016/S0960-894X(01)00780-6

Reference yield:

4-Nitrophenacyl bromide (99-81-0) → 7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester (474410-80-5)

Guidance literature:

Multi-step reaction with 5 steps

1: TBAF / tetrahydrofuran

2: NaH / tetrahydrofuran

3: TBAF / tetrahydrofuran

4: H₂ / Pd/C / acetic acid / 1551.44 Torr

5: Et₃N / tetrahydrofuran

With tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid;

DOI:10.1016/S0960-894X(01)00780-6

upstream raw materials:

o-fluorobenzyl bromide

ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate

4-Nitrophenacyl bromide

diethyl 2-ethoxymethylenemalonate