(2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS No.:173987-63-8
Molecular Formula:C₃₃H₃₆F₃NO₁₃Se
Molecular Weight:790.603
Hs Code.:

(2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

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Chemical Property of (2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

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Technology Process of (2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

There total 1 articles about (2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 85382-90-7
methyl-4,5,7,8-tetra-O-acetyl-2,6-anhydro-2,3-dideoxy-D-manno-oct-2-enosonat

: 115166-92-2
2-[4-(trifluoroacetylamino)phenyl]ethanol

: 173987-63-8
(2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; silver trifluoromethanesulfonate; Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, 2 h;
DOI:10.1016/0008-6215(95)00269-3

Reference yield:

: 173987-63-8
(2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

: 173987-64-9
methyl <2-(4-trifluoroacetamidophenyl)ethyl 4,5,7,8-tetra-O-acetyl-3-deoxy-α-D-manno-oct-2-ulopyranosid>onate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); triphenylstannane; In toluene; for 0.5h; Yield given; Heating;
DOI:10.1016/0008-6215(95)00269-3

Reference yield:

: 173987-63-8
(2S,3S,4S,5S,6R)-4,5-Diacetoxy-6-((R)-1,2-diacetoxy-ethyl)-3-phenylselanyl-2-{2-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-ethoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

: 173987-68-3
methyl <2-(4-trifluoroacetamidophenyl)ethyl 4-O-benzyl-3-deoxy-7,8-O-isopropylidene-5-O-(3,4,6-tri-O-acetyl-2-O-benzyl-α-D-glucopyranosyl)-α-D-manno-oct-2-ulopyranosid>onate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenyltin hydride, azobisisobutyronitrile / toluene / 0.5 h / Heating

2: NaOMe, MeOH / 2 h / Ambient temperature

3: p-toluenesulfonic acid / dimethylformamide / 20 h

4: 1.) dibutyltin oxide, 2.) tetrabutylammonium iodide, 3.) NaOMe, MeOH

5: 84 percent / dimethyl(methylthio)sulfonium trifluoromethanesulfonate, 4 Angstroem molecular sieves / CH₂Cl₂ / 18 h / 0 - 20 °C

With methanol; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; triphenylstannane; sodium methylate; tetra-(n-butyl)ammonium iodide; di(n-butyl)tin oxide; toluene-4-sulfonic acid; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(95)00269-3