(S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester

Base Information

• Chemical Name: (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester
• CAS No.: 129707-60-4
• Molecular Formula: C₂₅H₄₀N₂O₇S₂Si
• Molecular Weight: 572.819
• Mol file: 129707-60-4.mol

Synonyms:

Chemical Property of (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester

There total 3 articles about (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2) → (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester (129707-60-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 1.) BF₃*Et₂O, 2.) aq. NaHCO₃ / 1.) CH₂Cl₂, 23 deg C, 2.) 23 deg C

With boron trifluoride diethyl etherate; sodium hydrogencarbonate;

DOI:10.1021/ja00175a043

Reference yield:

vanillin (121-33-5,8014-42-4) → (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester (129707-60-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 1.) BF₃*Et₂O, 2.) aq. NaHCO₃ / 1.) CH₂Cl₂, 23 deg C, 2.) 23 deg C

With boron trifluoride diethyl etherate; sodium hydrogencarbonate;

DOI:10.1021/ja00175a043

Reference yield:

(S)-2-tert-Butoxycarbonylamino-pentane-bis-thioic acid di-S-ethyl ester (129679-78-3) + 4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoyl chloride (129679-77-2) → (S)-2-{4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoylamino}-pentane-bis-thioic acid di-S-ethyl ester (129707-60-4)

Guidance literature:

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) CH₂Cl₂, 23 deg C, 2.) 23 deg C;

DOI:10.1021/ja00175a043

upstream raw materials:

(S)-2-tert-Butoxycarbonylamino-pentane-bis-thioic acid di-S-ethyl ester

4-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-5-methoxy-2-nitro-benzoyl chloride

chlorodimethyl(1,1,2-trimethylpropyl)silane

vanillin

Downstream raw materials:

methyl neothramycin B