4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE

Base Information

• Chemical Name: 4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE
• CAS No.: 64178-58-1
• Molecular Formula: C4H3ClN2O2
• Molecular Weight: 146.533
• Hs Code.: 2933990090
• Mol file: 64178-58-1.mol

Synonyms:NSC 269136;5-Chloro-6-hydroxy-1H-pyridazin-4-one;4-Chloro-5-hydroxy-3(2h)-pyridazinone;

Chemical Property of 4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE

Chemical Property:

• Vapor Pressure: 0.0367mmHg at 25°C
• Melting Point: 270-273 °C(Solv: N,N-dimethylformamide (68-12-2))
• Refractive Index: 1.681
• Boiling Point: 213.3 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 82.8 °C
• PSA: 65.98000
• Density: 1.79 g/cm³
• LogP: 0.12890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-5-hydroxy-3(2H)-pyridazinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE

There total 4 articles about 4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-5-methoxypyridazin-3-(2H)-one (63910-43-0) → 4-chloro-5-hydroxy-3(2H)-pyridazinone (64178-58-1)

Guidance literature:

With hydrogen bromide; In acetic acid; for 6h; Heating;

DOI:10.1007/BF00811746

Reference yield: 54.0%

4,5-dichloro-2H-pyridazin-3-one (932-22-9) → 4-chloro-5-hydroxy-3(2H)-pyridazinone (64178-58-1)

Guidance literature:

With potassium hydroxide; for 6h; Heating;

DOI:10.1007/BF00811746

Reference yield: 39.0%

3,4-dichloro-5-methoxy-pyridazine (63910-32-7) → 4-chloro-5-hydroxy-3(2H)-pyridazinone (64178-58-1)

Guidance literature:

With hydrogenchloride; for 48h; Heating;

DOI:10.1007/BF00811746

upstream raw materials:

4,5-dichloro-2H-pyridazin-3-one

4-chloro-5-methoxypyridazin-3-(2H)-one

3,4-dichloro-5-methoxy-pyridazine

Downstream raw materials:

5-hydroxy-3(2H)-pyridazinone

Refernces