(R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride

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Chemical Name:(R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride
CAS No.:108869-15-4
Molecular Formula:2C₃₀H₃₂N₄O₂*3ClH
Molecular Weight:1070.6
Hs Code.:

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Chemical Property of (R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride

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Technology Process of (R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride

There total 8 articles about (R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 108869-15-4,108943-78-8,119677-90-6
(R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole hydrate (HBT) / dimethylformamide / Ambient temperature

2: HCl

With hydrogenchloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00390a019

Reference yield:

: 5241-64-5
Boc-D-Trp-OH

: 108869-15-4,108943-78-8,119677-90-6
(R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: HCl(g) / ethyl acetate / 0.33 h

3: aq. NaOH / methanol / 72 h / Ambient temperature

4: CF₃COOH, triethylsilane / 2 h / Ambient temperature

5: 47 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole hydrate (HBT) / dimethylformamide / Ambient temperature

6: HCl

With hydrogenchloride; triethylsilane; sodium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00390a019

Reference yield:

: 103342-83-2
(R)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

: 108869-15-4,108943-78-8,119677-90-6
(R)-3-[1-((S)-2-Amino-4-methyl-pentanoyl)-2,3-dihydro-1H-indol-3-ylmethyl]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: CF₃COOH, triethylsilane / 2 h / Ambient temperature

2: 47 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole hydrate (HBT) / dimethylformamide / Ambient temperature

3: HCl

With hydrogenchloride; triethylsilane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00390a019