C₄₇H₅₅N₅O₇S₂

Base Information

• Chemical Name: C₄₇H₅₅N₅O₇S₂
• CAS No.: 1447194-86-6
• Molecular Formula: C₄₇H₅₅N₅O₇S₂
• Molecular Weight: 866.115
• Mol file: 1447194-86-6.mol

Synonyms:

Chemical Property of C₄₇H₅₅N₅O₇S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₅N₅O₇S₂

There total 14 articles about C₄₇H₅₅N₅O₇S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H22N2O2S (1447195-14-3) + C30H35N3O6S → C47H55N5O7S2 (1447194-86-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 4.5h;

DOI:10.1002/anie.201302106

Reference yield:

Fmoc-Leu-OH (35661-60-0) → C47H55N5O7S2 (1447194-86-6)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogenchloride; 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

2: lithium aluminium tetrahydride / tetrahydrofuran / -25 °C

3: tin(ll) chloride / dichloromethane

4: sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

5: ethanol / 40 °C

6: diethylamine / d₇-N,N-dimethylformamide / 0.5 h / 20 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 4.5 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; sulfuryl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; d₇-N,N-dimethylformamide;

DOI:10.1002/anie.201302106

Reference yield:

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → C47H55N5O7S2 (1447194-86-6)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogenchloride; 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

2: lithium aluminium tetrahydride / tetrahydrofuran / -25 °C

3: tin(ll) chloride / dichloromethane

4: sulfuryl dichloride / dichloromethane / 1 h / 0 - 20 °C

5: ethanol / 40 °C

6: hydrogen; rosenmund catalyst / tetrahydrofuran; ethanol / 30 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 4.5 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; sulfuryl dichloride; rosenmund catalyst; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/anie.201302106

upstream raw materials:

Fmoc-Leu-OH

Fmoc-Lys(tert-butoxycarbonyl)

(9H-fluoren-9-yl)methyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

(S)-N-α-(fluorenylmethyloxycarbonyl)-N-ε-(tert-butyloxycarbonyl)-lysine N-methoxy-N-methylamide

Downstream raw materials:

C₃₂H₄₅N₅O₅S₂