(1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid
CAS No.:1435274-80-8
Molecular Formula:C₃₂H₃₃FO₄
Molecular Weight:500.61
Hs Code.:

(1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

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Chemical Property of (1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

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Technology Process of (1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

There total 7 articles about (1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₇FO₄

: 1435274-80-8
(1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 50 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ml300427u

Reference yield:

: 1435277-00-1
tert-butyldiphenyl(3-(prop-1-en-2-yl)phenoxy)silane

: 1435274-80-8
(1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dirhodium(II) tetracarboxylate / dichloromethane / 3 h / 20 - 45 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: AD-H column / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere

4: caesium carbonate / dimethyl sulfoxide / 16 h / 23 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran; ethanol / 15 h / 50 °C / Inert atmosphere

With dirhodium(II) tetracarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/ml300427u

Reference yield:

: 594813-04-4
1-(3-(tert-butyldiphenylsilyloxy)phenyl)ethanone

: 1435274-80-8
(1R,2R)-2-(3-(((2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)-2-methylcyclopropane carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: dirhodium(II) tetracarboxylate / dichloromethane / 3 h / 20 - 45 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: AD-H column / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere

5: caesium carbonate / dimethyl sulfoxide / 16 h / 23 °C / Inert atmosphere

6: water; lithium hydroxide / tetrahydrofuran; ethanol / 15 h / 50 °C / Inert atmosphere

With dirhodium(II) tetracarboxylate; potassium tert-butylate; tetrabutyl ammonium fluoride; water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/ml300427u