3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride

Base Information

Chemical Name:3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride
CAS No.:77992-29-1
Molecular Formula:C10H10 F3 N3 . Cl H
Molecular Weight:265.666
Hs Code.:2933199090
European Community (EC) Number:278-807-4
UNII:ZV0C22IUF1
DSSTox Substance ID:DTXSID80999246
Wikidata:Q27295900
Mol file:77992-29-1.mol

Synonyms:77992-29-1;3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride;UNII-ZV0C22IUF1;EINECS 278-807-4;ZV0C22IUF1;2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine;hydrochloride;4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine monohydrochloride;4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Hydrochloride;4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine monohydrochloride;C10H10F3N3.ClH;BW-755C HYDROCHLORIDE;SCHEMBL1040411;DTXSID80999246;C10-H10-F3-N3.Cl-H;Q27295900;3-amino-1-(3-tri-fluoromethylphenyl)-2-pyrazoline hydrochloride;4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine HCl;1-[3-(Trifluoromethyl)phenyl]pyrazolidin-3-imine--hydrogen chloride (1/1);3-AMINO-1-(M-(TRIFLUOROMETHYL)PHENYL)-2-PYRAZOLINE HYDROCHLORIDE;1-(3-trifluoromethyl-phenyl)-4,5-dihydro-1h-pyrazol-3-ylamine hydrochloride salt;1-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-ylamine hydrochloride;1H-PYRAZOL-3-AMINE, 4,5-DIHYDRO-1-(3-(TRIFLUOROMETHYL)PHENYL)-, MONOHYDROCHLORIDE;1H-PYRAZOL-3-AMINE, 4,5-DIHYDRO-1-(3-(TRIFLUOROMETHYL)PHENYL)-, MONOHYDROCHLORIDE-;1H-PYRAZOL-3-AMINE, 4,5-DIHYDRO-1-(3-(TRIFLUOROMETHYL)PHENYL)-, HYDROCHLORIDE (1:1)

Suppliers and Price of 3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amineHydrochloride
1g
$ 1175.00

TRC
4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amineHydrochloride
100mg
$ 145.00

Total 6 raw suppliers

Chemical Property of 3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride

Chemical Property:

Vapor Pressure:0.00068mmHg at 25°C
Boiling Point:308.5°C at 760 mmHg
Flash Point:140.4°C
PSA：39.12000
LogP:3.69290
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:265.0593595
Heavy Atom Count:17
Complexity:288

Purity/Quality:

99% ^*data from raw suppliers

4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(N=C1N)C2=CC=CC(=C2)C(F)(F)F.Cl
Uses 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Hydrochloride is used as a reagent in the synthesis of benzimidazolylbiarylacetamides as vanilloid TRVP1 inhibitors for the treatment of pain and respiratory disorders.

Technology Process of 3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride

There total 2 articles about 3-Amino-1-(3-(trifluoromethyl)phenyl)-2-pyrazoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 107-13-1,25014-41-9
acrylonitrile

: 368-78-5
3-(trifluoromethyl)phenylhydrazine

: 77992-29-1
3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride

Guidance literature:: acrylonitrile; 3-(trifluoromethyl)phenylhydrazine; With sodium ethanolate; In ethanol; for 24h; Heating / reflux;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 77992-29-1
3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride

Guidance literature:

Reference yield: 86.0%

: 77992-29-1
3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride

: 1-(3-trifluoromethyl-phenyl)-1H-pyrazol-3-ylamine hydrochloride

Guidance literature:: 3-amino-1-(3-trifluoromethylphenyl)-2-pyrazoline hydrochloride; With triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; at 20 ℃; for 24h;

With hydrogenchloride; In diethyl ether;