[(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester
• CAS No.: 215512-31-5
• Molecular Formula: C₆₇H₇₇N₇O₁₁
• Molecular Weight: 1156.39
• Mol file: 215512-31-5.mol

Synonyms:

Chemical Property of [(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester

There total 1 articles about [(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Lys(Fmoc)-OH (84624-27-1) + [(S)-5-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-5-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-carbamic acid benzyl ester; compound with trifluoro-acetic acid → [(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester (215512-31-5)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80043-3

Reference yield:

[(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester (215512-31-5) → [(2S,5S,8S,23S)-2,5-Dibenzyl-8-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3,6,14,17,24-pentaoxo-1,4,7,13,18-pentaaza-cyclotetracos-23-yl]-carbamic acid tert-butyl ester (215511-39-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₂NH / dimethylformamide

2: iPr₂NEt / dimethylformamide

3: H₂ / Pd/C

4: BOP, NaHCO₃ / dimethylformamide / Ambient temperature

With hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80043-3

Reference yield:

[(S)-1-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl]-carbamic acid tert-butyl ester (215512-31-5) → N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Amino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid (1025993-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₂NH / dimethylformamide

2: iPr₂NEt / dimethylformamide

3: H₂ / Pd/C

With hydrogen; diethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80043-3

upstream raw materials:

Boc-Lys(Fmoc)-OH

Downstream raw materials:

[(2S,5S,8S,23S)-2,5-Dibenzyl-8-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3,6,14,17,24-pentaoxo-1,4,7,13,18-pentaaza-cyclotetracos-23-yl]-carbamic acid tert-butyl ester

N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Amino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid

N-[(S)-5-((S)-1-{(S)-1-[(S)-5-Benzyloxycarbonylamino-1-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-succinamic acid